A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E.
about
The generation and function of soluble apoE receptors in the CNSLDL receptor-related protein LRP6 regulates proliferation and survival through the Wnt cascade in vascular smooth muscle cellsModulation of LRP6-mediated Wnt signaling by molecular chaperone MesdMutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.LRP5 in premature adrenarche and in metabolic characteristics of prepubertal childrenPatients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cellsLow-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretionA mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass traitLRP5 and LRP6 in development and diseaseHigh bone mass in mice expressing a mutant LRP5 geneThe ups and downs of Wnt signaling in prevalent neurological disordersWhere Wnts went: the exploding field of Lrp5 and Lrp6 signaling in boneAnalysis of a two-domain binding site for the urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex in low-density-lipoprotein-receptor-related proteinDecreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptorLrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisitionInhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cellsWnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.Mechanisms of aortic valve calcification: the LDL-density-radius theory: a translation from cell signaling to physiology.Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.The WNT signalling pathway and diabetes mellitus.The role of Lrp5/6 in cardiac valve disease: experimental hypercholesterolemia in the ApoE-/- /Lrp5-/- mice.Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's diseaseLRP5 and Wnt signaling: a union made for bone.Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesisThe role of Lrp5/6 in cardiac valve disease: LDL-density-pressure theory.Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway.Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway.Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance.Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis.Low-Density Lipoprotein Receptor-Related Proteins in Skeletal Development and Disease.Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes.Shunts, channels and lipoprotein endosomal traffic: a new model of cholesterol homeostasis in the hepatocyte.Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signalingNew horizons for lipoprotein receptors: communication by β-propellers.LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease.The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan.Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E.Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer's Disease.Low-density lipoprotein receptor-related protein 5 variant Q89R is associated with hypertension in Japanese females.
P2860
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P2860
A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
A new low density lipoprotein ...... d recognizes apolipoprotein E.
@en
A new low density lipoprotein ...... d recognizes apolipoprotein E.
@nl
type
label
A new low density lipoprotein ...... d recognizes apolipoprotein E.
@en
A new low density lipoprotein ...... d recognizes apolipoprotein E.
@nl
prefLabel
A new low density lipoprotein ...... d recognizes apolipoprotein E.
@en
A new low density lipoprotein ...... d recognizes apolipoprotein E.
@nl
P2093
P1476
A new low density lipoprotein ...... d recognizes apolipoprotein E.
@en
P2093
P304
P356
10.1093/OXFORDJOURNALS.JBCHEM.A022223
P577
1998-12-01T00:00:00Z