about
Potential Modulation of Sirtuins by Oxidative StressSirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins.The ways and means that fine tune Sirt1 activity.Deleted in Breast Cancer 1 regulates cellular senescence during obesityDysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence.The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest.DBC1 functions as a tumor suppressor by regulating p53 stabilityA divergent role of the SIRT1-TopBP1 axis in regulating metabolic checkpoint and DNA damage checkpoint.Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivoThe N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional OutputsRole of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.Acetylation at lysine 71 inactivates superoxide dismutase 1 and sensitizes cancer cells to genotoxic agents.Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.The Proteomic Profile of Deleted in Breast Cancer 1 (DBC1) Interactions Points to a Multifaceted Regulation of Gene ExpressionHIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanismSirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenanceCrosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancerThe Roles of SIRT1 in Cancer.Stress Inducibility of SIRT1 and Its Role in Cytoprotection and Cancer.SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1.Role of multifunctional transcription factor TFII-I and putative tumour suppressor DBC1 in cell cycle and DNA double strand damage repair.hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1.SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism.SIRT1 metabolic actions: Integrating recent advances from mouse models.Sirtuins and the Metabolic Hurdles in Cancer.CCAR2 Is Required for Proliferation and Tumor Maintenance in Human Squamous Cell Carcinoma.CCAR2/DBC1 is required for Chk2-dependent KAP1 phosphorylation and repair of DNA damage.Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage.Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis.Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism.DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage.The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling.NRAGE is involved in homologous recombination repair to resist the DNA-damaging chemotherapy and composes a ternary complex with RNF8-BARD1 to promote cell survival in squamous esophageal tumorigenesis.Interplay between Intravitreal RvD1 and Local Endogenous Sirtuin-1 in the Protection from Endotoxin-Induced Uveitis in Rats.DBC1 is phosphorylated by ATM/ARTCCAR2 deficiency augments genotoxic stress-induced apoptosis in the presence of melatonin in non-small cell lung cancer cells.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Regulation of SIRT1 activity by genotoxic stress.
@ast
Regulation of SIRT1 activity by genotoxic stress.
@en
type
label
Regulation of SIRT1 activity by genotoxic stress.
@ast
Regulation of SIRT1 activity by genotoxic stress.
@en
prefLabel
Regulation of SIRT1 activity by genotoxic stress.
@ast
Regulation of SIRT1 activity by genotoxic stress.
@en
P2093
P2860
P356
P1433
P1476
Regulation of SIRT1 activity by genotoxic stress.
@en
P2093
Kuntian Luo
Tongzheng Liu
Zhenkun Lou
P2860
P304
P356
10.1101/GAD.188482.112
P577
2012-03-30T00:00:00Z