Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.
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The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinityWhere CD4+CD25+ T reg cells impinge on autoimmune diabetesTracking autoimmune T cells in diabetes.Peripherin-reactive antibodies in mouse, rabbit, and human blood.Mouse Models for Type 1 Diabetes.Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3Induction of mixed chimerism with MHC-mismatched but not matched bone marrow transplants results in thymic deletion of host-type autoreactive T-cells in NOD micePopulation dynamics of islet-infiltrating cells in autoimmune diabetes.Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapiesUse of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetesSpontaneous myocarditis mimicking human disease occurs in the presence of an appropriate MHC and non-MHC background in transgenic mice.Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3.Cutting Edge: Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes.CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion.Modifier loci condition autoimmunity provoked by Aire deficiency.Antidiabetogenic MHC class II promotes the differentiation of MHC-promiscuous autoreactive T cells into FOXP3+ regulatory T cells.Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice.Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusionIdd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice.Novel autoantigens for diabetogenic CD4 T cells in autoimmune diabetes.Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?The genetics of multiple sclerosis: SNPs to pathways to pathogenesis.Cutting edge: CD4 T cells reactive to an islet amyloid polypeptide peptide accumulate in the pancreas and contribute to disease pathogenesis in nonobese diabetic mice.Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice.CD8+ dendritic cell-mediated tolerance of autoreactive CD4+ T cells is deficient in NOD mice and can be corrected by blocking CD40L.Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitisDelineating the role of the HLA-DR4 "shared epitope" in susceptibility versus resistance to develop arthritis.Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD miceIn vivo detection of peripherin-specific autoreactive B cells during type 1 diabetes pathogenesis.The influence of the microbiota on type-1 diabetes: on the threshold of a leap forward in our understanding.Expanding antigen-specific regulatory networks to treat autoimmunity.Host-derived CD4+ T cells attenuate stem cell-mediated transfer of autoimmune arthritis in lethally irradiated C57BL/6.g7 mice.B6.g7 mice reconstituted with BDC2·5 non-obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes.In situ staining using MHC class I tetramers.Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis.MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice.Conditioning the genome identifies additional diabetes resistance loci in Type I diabetes resistant NOR/Lt mice.Treatment of T1D via optimized expansion of antigen-specific Tregs induced by IL-2/anti-IL-2 monoclonal antibody complexes and peptide/MHC tetramers.
P2860
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P2860
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.
@ast
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.
@en
type
label
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.
@ast
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.
@en
prefLabel
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.
@ast
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.
@en
P2093
P2860
P356
P1476
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.
@en
P2093
Cathleen M Dobbs
Christophe Benoist
Diane Mathis
Dorian McGavern
Grigoriy Losyev
Hitoshi Kikutani
Kathryn Haskins
Kenji Yoshida
Laurent Poirot
Luc Teyton
P2860
P304
P356
10.1172/JCI18337
P407
P577
2003-09-01T00:00:00Z