Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice
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Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targetsLymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patientsThe self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.Cutting edge: identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade.Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T CellsCutting Edge: Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes.An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients.CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursorsEfficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.PD-1 pathway-mediated regulation of islet-specific CD4+ T cell subsets in autoimmune diabetesPerinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes.Programmed Death-1 Culls Peripheral Accumulation of High-Affinity Autoreactive CD4 T Cells to Protect against AutoimmunityMechanisms of autoimmunity in the non-obese diabetic mouse: effector/regulatory cell equilibrium during peak inflammation.Relationship between CD4 Regulatory T Cells and Anergy In Vivo.The Induction and Maintenance of Transplant Tolerance Engages Both Regulatory and Anergic CD4+ T cells.Retinal antigen-specific regulatory T cells protect against spontaneous and induced autoimmunity and require local dendritic cells.T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes.Increased Effector Memory Insulin-Specific CD4+ T Cells Correlate With Insulin Autoantibodies in Patients With Recent-Onset Type 1 Diabetes.Ectopic Expression of Self-Antigen Drives Regulatory T Cell Development and Not Deletion of Autoimmune T Cells.Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes.Treatment of T1D via optimized expansion of antigen-specific Tregs induced by IL-2/anti-IL-2 monoclonal antibody complexes and peptide/MHC tetramers.
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Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice
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article científic
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artigo científico
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bilimsel makale
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scientific article published on 11 October 2013
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Cutting edge: type 1 diabetes ...... ecific CD4 T cells in NOD mice
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Cutting edge: type 1 diabetes ...... cific CD4 T cells in NOD mice.
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type
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Cutting edge: type 1 diabetes ...... ecific CD4 T cells in NOD mice
@en
Cutting edge: type 1 diabetes ...... cific CD4 T cells in NOD mice.
@nl
prefLabel
Cutting edge: type 1 diabetes ...... ecific CD4 T cells in NOD mice
@en
Cutting edge: type 1 diabetes ...... cific CD4 T cells in NOD mice.
@nl
P2093
P2860
P50
P356
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Cutting edge: type 1 diabetes ...... ecific CD4 T cells in NOD mice
@en
P2093
James J Moon
Jonathan L Linehan
Kristen E Pauken
Lokesh A Kalekar
Nathanael L Sahli
P2860
P304
P356
10.4049/JIMMUNOL.1301927
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P577
2013-10-11T00:00:00Z