Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma.
about
Electrophysiological assessment of retinal ganglion cell functionA molecular mechanism for glaucoma: endoplasmic reticulum stress and the unfolded protein responseRestoration of mutant bestrophin-1 expression, localisation and function in a polarised epithelial cell modelER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate.Common and rare genetic risk factors for glaucoma.A role for myocilin in receptor-mediated endocytosis.Structural basis for misfolding in myocilin-associated glaucoma.Increased Endoplasmic Reticulum Stress in Human Glaucomatous Trabecular Meshwork Cells and Tissues.Proteomics Analysis of Molecular Risk Factors in the Ocular Hypertensive Human RetinaWhole exome sequencing implicates eye development, the unfolded protein response and plasma membrane homeostasis in primary open-angle glaucoma.Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.Molecular biomarkers in glaucomaA de novo MYOC mutation detected in juvenile open angle glaucoma associated with reduced myocilin protein in aqueous humor.Review: retinal degeneration: focus on the unfolded protein response.A Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture.Tank-Binding Kinase 1 (TBK1) Gene and Open-Angle Glaucomas (An American Ophthalmological Society Thesis).The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review.Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma.Genetics of Primary Inherited Disorders of the Optic Nerve: Clinical Applications.Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.Stem Cells in the Trabecular Meshwork for Regulating Intraocular Pressure.Major review: Molecular genetics of primary open-angle glaucoma.Duplication of TBK1 Stimulates Autophagy in iPSC-derived Retinal Cells from a Patient with Normal Tension Glaucoma.The Unfolded Protein Response in Amelogenesis and Enamel Pathologies.Suppression of fibrosis in human pterygium fibroblasts by butyrate and phenylbutyrate.CRISPR-Cas9-based treatment of myocilin-associated glaucomaIsoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma.Methods for Analyzing Endoplasmic Reticulum Stress in the Trabecular Meshwork of Glaucoma Models.Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders.Genetics of glaucoma.New direction for glaucoma therapeutics: focus on the olfactomedin domain of myocilin.BEST1 protein stability and degradation pathways differ between autosomal dominant Best disease and autosomal recessive bestrophinopathy accounting for the distinct retinal phenotypes.
P2860
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P2860
Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Topical ocular sodium 4-phenyl ...... f primary open-angle glaucoma.
@ast
Topical ocular sodium 4-phenyl ...... f primary open-angle glaucoma.
@en
type
label
Topical ocular sodium 4-phenyl ...... f primary open-angle glaucoma.
@ast
Topical ocular sodium 4-phenyl ...... f primary open-angle glaucoma.
@en
prefLabel
Topical ocular sodium 4-phenyl ...... f primary open-angle glaucoma.
@ast
Topical ocular sodium 4-phenyl ...... f primary open-angle glaucoma.
@en
P2093
P2860
P50
P356
P1476
Topical ocular sodium 4-phenyl ...... of primary open-angle glaucoma
@en
P2093
Demelza R Koehn
Gulab S Zode
Joseph C Peters
Kabhilan Mohan
Kevin E Bugge
Sinisa D Grozdanic
P2860
P304
P356
10.1167/IOVS.11-8837
P407
P577
2012-03-21T00:00:00Z