about
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchangeP90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferationInduction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stressThe combinatorial nature of osmosensing in fishesCell cycle progression by the repression of primary cilia formation in proliferating cellsFormation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrestPhosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint.Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?Rad4 mainly functions in Chk1-mediated DNA damage checkpoint pathway as a scaffold protein in the fission yeast Schizosaccharomyces pombep38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replicationATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway functionThe yeast DNA damage checkpoint proteins control a cytoplasmic response to DNA damageOpposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.The involvement of ataxia-telangiectasia mutated protein activation in nucleotide excision repair-facilitated cell survival with cisplatin treatment.HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase.Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair.Crosstalk between the DNA damage response, histone modifications and neovascularisation.Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control.DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cellsCytochrome oxidase deficiency protects Escherichia coli from cell death but not from filamentation due to thymine deficiency or DNA polymerase inactivationReconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer.The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpointH2AX phosphorylation screen of cells from radiosensitive cancer patients reveals a novel DNA double-strand break repair cellular phenotype.Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response.ATM-NF-kappaB connection as a target for tumor radiosensitizationPhosphatases in the cellular response to DNA damage.Interdependent phosphorylation within the kinase domain T-loop Regulates CHK2 activitySlx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1.Coordination of DNA synthesis and replicative unwinding by the S-phase checkpoint pathways.Wat1/pop3, a conserved WD repeat containing protein acts synergistically with checkpoint kinase Chk1 to maintain genome ploidy in fission yeast S. pombeA point mutation in the Aspergillus nidulans sonBNup98 nuclear pore complex gene causes conditional DNA damage sensitivityRegulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair.Essential role of chromatin assembly factor-1-mediated rapid nucleosome assembly for DNA replication and cell division in vertebrate cellsThe breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis.Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts.Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45α-dependent manner.Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replicationHeterochromatin is refractory to gamma-H2AX modification in yeast and mammalsAn FHA domain-mediated protein interaction network of Rad53 reveals its role in polarized cell growth.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The DNA damage response: sensing and signaling.
@ast
The DNA damage response: sensing and signaling.
@en
type
label
The DNA damage response: sensing and signaling.
@ast
The DNA damage response: sensing and signaling.
@en
prefLabel
The DNA damage response: sensing and signaling.
@ast
The DNA damage response: sensing and signaling.
@en
P1476
The DNA damage response: sensing and signaling.
@en
P2093
Clare H McGowan
Paul Russell
P304
P356
10.1016/J.CEB.2004.09.005
P577
2004-12-01T00:00:00Z