Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication - Wikidata - wikimedia - TriplyDB

Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication

Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication

http://www.wikidata.org/entity/Q36082611

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The DNA damage response induced by infection with human cytomegalovirus and other viruses Phosphoproteomic analyses reveal signaling pathways that facilitate lytic gammaherpesvirus replication Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication The papillomavirus E1 helicase activates a cellular DNA damage response in viral replication foci GammaH2AX and cancer MHV68 complement regulatory protein facilitates MHV68 replication in primary macrophages in a complement independent manner.Murine gammaherpesvirus 68 has evolved gamma interferon and stat1-repressible promoters for the lytic switch gene 50.Chromatin at the intersection of viral infection and DNA damage Interferon regulatory factor 1 restricts gammaherpesvirus replication in primary immune cells.Noise cancellation: viral fine tuning of the cellular environment for its own genome replication.An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus.The DNA damage response in viral-induced cellular transformation Histone deacetylases and the nuclear receptor corepressor regulate lytic-latent switch gene 50 in murine gammaherpesvirus 68-infected macrophages Epstein-Barr virus BGLF4 kinase retards cellular S-phase progression and induces chromosomal abnormality.Gammaherpesvirus gene expression and DNA synthesis are facilitated by viral protein kinase and histone variant H2AX.Dynamic association of gammaherpesvirus DNA with core histone during de novo lytic infection of primary cells.DNA Damage Signaling Is Induced in the Absence of Epstein-Barr Virus (EBV) Lytic DNA Replication and in Response to Expression of ZEBRA.Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication.The UL13 and US3 Protein Kinases of Herpes Simplex Virus 1 Cooperate to Promote the Assembly and Release of Mature, Infectious Virions.What's the damage? The impact of pathogens on pathways that maintain host genome integrity Regulation of DNA Damage Signaling and Cell Death Responses by Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) and LMP2A in Nasopharyngeal Carcinoma Cells.Tiled microarray identification of novel viral transcript structures and distinct transcriptional profiles during two modes of productive murine gammaherpesvirus 68 infection.ATM facilitates mouse gammaherpesvirus reactivation from myeloid cells during chronic infection.Direct evidence that HSV DNA damaged by ultraviolet (UV) irradiation can be repaired in a cell type-dependent manner.Coordinate regulation of DNA damage and type I interferon responses imposes an antiviral state that attenuates mouse gammaherpesvirus type 68 replication in primary macrophages.Ataxia telangiectasia mutated kinase controls chronic gammaherpesvirus infection.The cellular ataxia telangiectasia-mutated kinase promotes epstein-barr virus lytic reactivation in response to multiple different types of lytic reactivation-inducing stimuli Activation of H2AX and ATM in varicella-zoster virus (VZV)-infected cells is associated with expression of specific VZV genes Type I Interferon Counteracts Antiviral Effects of Statins in the Context of Gammaherpesvirus Infection.Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication Infection of a Single Cell Line with Distinct Strains of Human Cytomegalovirus Can Result in Large Variations in Virion Production and Facilitate Efficient Screening of Virus Protein Function.H2AX phosphorylation is important for LANA-mediated Kaposi's sarcoma-associated herpesvirus episome persistence.γ-H2AX+CD8+ T lymphocytes cannot respond to IFN-α, IL-2 or IL-6 in chronic hepatitis C virus infection Establishment of B-cell lines latently infected with reactivation-competent murine gammaherpesvirus 68 provides evidence for viral alteration of a DNA damage-signaling cascade.Hijacking the DNA damage response to enhance viral replication: gamma-herpesvirus 68 orf36 phosphorylates histone H2AX.Cell cycle-independent expression of immediate-early gene 3 results in G1 and G2 arrest in murine cytomegalovirus-infected cells.Epstein-Barr virus BGLF4 kinase induces disassembly of the nuclear lamina to facilitate virion production Chromatin organization and virus gene expression.Protein array identification of substrates of the Epstein-Barr virus protein kinase BGLF4 Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication.

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Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication

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2007 nî lūn-bûn

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Gamma-herpesvirus kinase activ ...... AX to foster viral replication

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Gamma-herpesvirus kinase activ ...... AX to foster viral replication

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J.CHOM.2007.05.008

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Cell Host & Microbe

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Gamma-herpesvirus kinase activ ...... AX to foster viral replication

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Barry P Sleckman

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Chiao-Wen Yang

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Helen Piwnica-Worms

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Katie Matatall

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Mickael Basson

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Ren Sun

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Seungmin Hwang

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Van Leung-Pineda

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Vera L Tarakanova

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P2860

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo.

Complete sequence and genomic analysis of murine gammaherpesvirus 68

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

Genomic instability in mice lacking histone H2AX

Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

Epstein-Barr virus: 40 years on

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275-286

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10.1016/J.CHOM.2007.05.008

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4

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1

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Herbert W. "Skip" Virgin

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2007-06-01T00:00:00Z

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5840755

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18005708

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phosphorylation

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2034359

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