Coreceptor switch in R5-tropic simian/human immunodeficiency virus-infected macaques
about
SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeysPhylodynamics of HIV-1 in lymphoid and non-lymphoid tissues reveals a central role for the thymus in emergence of CXCR4-using quasispeciesUnderstanding the HIV coreceptor switch from a dynamical perspective.Different tempo and anatomic location of dual-tropic and X4 virus emergence in a model of R5 simian-human immunodeficiency virus infection.Evolution of the HIV-1 env gene in the Rag2-/- gammaC-/- humanized mouse modelGeneration of the pathogenic R5-tropic simian/human immunodeficiency virus SHIVAD8 by serial passaging in rhesus macaquesAdoption of an "open" envelope conformation facilitating CD4 binding and structural remodeling precedes coreceptor switch in R5 SHIV-infected macaques.Emergence of CD4 independence envelopes and astrocyte infection in R5 simian-human immunodeficiency virus model of encephalitis.Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain's exceptional capacity for sequence variation.Development of co-selected single nucleotide polymorphisms in the viral promoter precedes the onset of human immunodeficiency virus type 1-associated neurocognitive impairment.Effect of B-cell depletion on coreceptor switching in R5 simian-human immunodeficiency virus infection of rhesus macaques.Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entryIn vitro neutralization of low dose inocula at physiological concentrations of a monoclonal antibody which protects macaques against SHIV challenge.Giant cell encephalitis and microglial infection with mucosally transmitted simian-human immunodeficiency virus SHIVSF162P3N in rhesus macaquesRecombination-mediated changes in coreceptor usage confer an augmented pathogenic phenotype in a nonhuman primate model of HIV-1-induced AIDS.Development of a tier 1 R5 clade C simian-human immunodeficiency virus as a tool to test neutralizing antibody-based immunoprophylaxis.Incomplete APOBEC3G/F Neutralization by HIV-1 Vif Mutants Facilitates the Genetic Evolution from CCR5 to CXCR4 Usage.Molecularly cloned SHIV-CN97001: a replication-competent, R5 simian/human immunodeficiency virus containing env of a primary Chinese HIV-1 clade C isolate.Pathogenic consequences of vaginal infection with CCR5-tropic simian-human immunodeficiency virus SHIVSF162P3N.Pathogenicity and mucosal transmissibility of the R5-tropic simian/human immunodeficiency virus SHIV(AD8) in rhesus macaques: implications for use in vaccine studies.Identification of interdependent variables that influence coreceptor switch in R5 SHIV(SF162P3N)-infected macaques.In silico Analysis of HIV-1 Env-gp120 Reveals Structural Bases for Viral Adaptation in Growth-Restrictive Cells.Mucosal transmissibility, disease induction and coreceptor switching of R5 SHIVSF162P3N molecular clones in rhesus macaques.Different mutational pathways to CXCR4 coreceptor switch of CCR5-using simian-human immunodeficiency virusDevelopment of Broadly Neutralizing Antibodies and Their Mapping by Monomeric gp120 in Human Immunodeficiency Virus Type 1-Infected Humans and Simian-Human Immunodeficiency Virus SHIVSF162P3N-Infected Macaques.R5X4 viruses are evolutionary, functional, and antigenic intermediates in the pathway of a simian-human immunodeficiency virus coreceptor switchEfficient mucosal transmissibility but limited pathogenicity of R5 SHIV SF162P3N in Chinese-origin rhesus macaques.Generation of lineage-related, mucosally transmissible subtype C R5 simian-human immunodeficiency viruses capable of AIDS development, induction of neurological disease, and coreceptor switching in rhesus macaques.Genotypic Prediction of Co-receptor Tropism of HIV-1 Subtypes A and CThe HIV-1 env protein: a coat of many colors.Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants.Derivation and characterization of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4.Coreceptor use in nonhuman primate models of HIV infection.A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects.High-Sequence Diversity and Rapid Virus Turnover Contribute to Higher Rates of Coreceptor Switching in Treatment-Experienced Subjects with HIV-1 Viremia.Fitness disadvantage of transitional intermediates contributes to dynamic change in the infecting-virus population during coreceptor switch in R5 simian/human immunodeficiency virus-infected macaques.Evolution of CCR5 use before and during coreceptor switchingThe R5 to X4 coreceptor switch: a dead-end path, or a strategic maneuver? Lessons from a game theoretic analysis.A novel strategy to adapt SHIV-E1 carrying env from an RV144 volunteer to rhesus macaques: coreceptor switch and final recovery of a pathogenic virus with exclusive R5 tropism.Gp120 V5 Is Targeted by the First Wave of Sequential Neutralizing Antibodies in SHIVSF162P3N-Infected Rhesus Macaques.
P2860
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P2860
Coreceptor switch in R5-tropic simian/human immunodeficiency virus-infected macaques
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Coreceptor switch in R5-tropic simian/human immunodeficiency virus-infected macaques
@ast
Coreceptor switch in R5-tropic simian/human immunodeficiency virus-infected macaques
@en
type
label
Coreceptor switch in R5-tropic simian/human immunodeficiency virus-infected macaques
@ast
Coreceptor switch in R5-tropic simian/human immunodeficiency virus-infected macaques
@en
prefLabel
Coreceptor switch in R5-tropic simian/human immunodeficiency virus-infected macaques
@ast
Coreceptor switch in R5-tropic simian/human immunodeficiency virus-infected macaques
@en
P2093
P2860
P356
P1433
P1476
Coreceptor switch in R5-tropic simian/human immunodeficiency virus-infected macaques
@en
P2093
Agegnehu Gettie
Cecilia Cheng-Mayer
Daniel Boden
James Blanchard
Silvana Tasca
Siu-hong Ho
P2860
P304
P356
10.1128/JVI.00759-07
P407
P577
2007-05-30T00:00:00Z