Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies. - Wikidata - wikimedia - TriplyDB

Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies.

Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies.

http://www.wikidata.org/entity/Q35962978

about

A transposon and transposase system for human application The Sleeping Beauty transposon system: a non-viral vector for gene therapy Novel immunotherapies in lymphoid malignancies T-cell and natural killer cell therapies for hematologic malignancies after hematopoietic stem cell transplantation: enhancing the graft-versus-leukemia effect CARs in chronic lymphocytic leukemia -- ready to drive Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies CD19-Chimeric Antigen Receptor T Cells for Treatment of Chronic Lymphocytic Leukaemia and Acute Lymphoblastic Leukaemia Novel therapeutic approaches for various cancer types using a modified sleeping beauty-based gene delivery system DNA transposon-based gene vehicles - scenes from an evolutionary drive piggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignancies.Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses.Advances of CD19-directed chimeric antigen receptor-modified T cells in refractory/relapsed acute lymphoblastic leukemia 4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor Combining CD19 redirection and alloanergization to generate tumor-specific human T cells for allogeneic cell therapy of B-cell malignancies.Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor.Translating Sleeping Beauty transposition into cellular therapies: victories and challenges.Gene transfer efficiency and genome-wide integration profiling of Sleeping Beauty, Tol2, and piggyBac transposons in human primary T cells Immunotherapy of human cancers using gene modified T lymphocytes.Unexpectedly high copy number of random integration but low frequency of persistent expression of the Sleeping Beauty transposase after trans delivery in primary human T cells.The impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells.Inhibition of angiogenesis and suppression of colorectal cancer metastatic to the liver using the Sleeping Beauty Transposon System The promise and potential pitfalls of chimeric antigen receptors.MicroRNA-146a and microRNA-146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteins IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas.Chimeric antigen receptor-engineered T cells for the treatment of metastatic prostate cancer.Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers.Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity.Efficient sleeping beauty DNA transposition from DNA minicircles.Clinical application of Sleeping Beauty and artificial antigen presenting cells to genetically modify T cells from peripheral and umbilical cord blood.Role of microRNAs in lung development and pulmonary diseases Adoptive immunotherapy: good habits instilled at youth have long-term benefits.Immunotherapeutic approaches for glioma Highlights of the First International "Immunotherapy in Pediatric Oncology: Progress and Challenges" Meeting.Treatment of lymphoma with adoptively transferred T cells.Chimeric antibody receptors (CARs): driving T-cell specificity to enhance anti-tumor immunity Genome-wide mapping of PiggyBac transposon integrations in primary human T cells.Fifteen years of gene therapy based on chimeric antigen receptors: "are we nearly there yet?".Immunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved Sleeping Beauty transposon platform.Genetic redirection of T cells for cancer therapy.

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P2860

Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies.

http://www.wikidata.org/entity/Q35962978

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Sleeping Beauty transposon-med ...... f CD19+ lymphoid malignancies.

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Sleeping Beauty transposon-med ...... f CD19+ lymphoid malignancies.

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type

label

Sleeping Beauty transposon-med ...... f CD19+ lymphoid malignancies.

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Sleeping Beauty transposon-med ...... f CD19+ lymphoid malignancies.

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Sleeping Beauty transposon-med ...... f CD19+ lymphoid malignancies.

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Sleeping Beauty transposon-med ...... f CD19+ lymphoid malignancies.

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P1433

Molecular Therapy

P1476

Sleeping Beauty transposon-med ...... f CD19+ lymphoid malignancies.

@en

P2093

Bruce L Levine

http://www.w3.org/2001/XMLSchema#string

Carl H June

http://www.w3.org/2001/XMLSchema#string

Christopher J Lees

http://www.w3.org/2001/XMLSchema#string

Hongfeng Guo

http://www.w3.org/2001/XMLSchema#string

John E Wagner

http://www.w3.org/2001/XMLSchema#string

Johnthomas Kang

http://www.w3.org/2001/XMLSchema#string

Michael Milone

http://www.w3.org/2001/XMLSchema#string

R Scott McIvor

http://www.w3.org/2001/XMLSchema#string

Suet Choi

http://www.w3.org/2001/XMLSchema#string

Syam Tammana

http://www.w3.org/2001/XMLSchema#string

P2860

High-resolution genome-wide mapping of transposon integration in mammals.

Central memory and effector memory T cell subsets: function, generation, and maintenance

Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells

Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy.

Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells

Mammalian germ-line transgenesis by transposition.

Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon.

Gene transfer into genomes of human cells by the sleeping beauty transposon system.

Sleeping beauty transposition: biology and applications for molecular therapy.

CD4 T cells in tumor immunity.

P304

580-589

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scholarly article

P356

10.1038/SJ.MT.6300404

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3

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P478

16

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2008-01-29T00:00:00Z

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18227839

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4539139

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