The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate
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Activating Smoothened mutations in sporadic basal-cell carcinomaN-Arachidonyl glycine does not activate G protein-coupled receptor 18 signaling via canonical pathwaysConstitutive activation of A(3) adenosine receptors by site-directed mutagenesisOverexpression of kinin B1 receptors induces hypertensive response to des-Arg9-bradykinin and susceptibility to inflammationDisruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival.Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptorMolecular basis of ligand binding and receptor activation in the oxytocin and vasopressin receptor family.Homology model of the CB1 cannabinoid receptor: sites critical for nonclassical cannabinoid agonist interaction.Comparison of class A and D G protein-coupled receptors: common features in structure and activation.The α1-adrenergic receptors: diversity of signaling networks and regulationDominant-negative activity of an alpha(1B)-adrenergic receptor signal-inactivating point mutation.Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation.The significance of G protein-coupled receptor crystallography for drug discovery.Conformational changes of G protein-coupled receptors during their activation by agonist binding.Differential Virtual Screening (DVS) with Active and Inactive Molecular Models for Finding and Profiling GPCR Modulators: Case of the CCK1 Receptor.Selectivity in the Use of Gi/o Proteins Is Determined by the DRF Motif in CXCR6 and Is Cell-Type Specific.Sequence of late molecular events in the activation of rhodopsin.Functional analysis of the murine cytomegalovirus chemokine receptor homologue M33: ablation of constitutive signaling is associated with an attenuated phenotype in vivo.Modeling and simulation of the human delta opioid receptor.Structure and function in rhodopsin: rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state.Identification and functional characterisation of 5-HT4 receptor in sea cucumber Apostichopus japonicus (Selenka).Proteins of the Hedgehog signaling pathway as therapeutic targets against cancer.Role of the highly conserved Asp-Arg-Tyr motif in signal transduction of the CB2 cannabinoid receptor.Advances in methods to characterize ligand-induced ionic lock and rotamer toggle molecular switch in G protein-coupled receptorsRole of the ERC motif in the proximal part of the second intracellular loop and the C-terminal domain of the human prostaglandin F2alpha receptor (hFP-R) in G-protein coupling control.Galpha protein selectivity determinant specified by a viral chemokine receptor-conserved region in the C tail of the human herpesvirus 8 g protein-coupled receptor.Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.Chlorpropamide upregulates antidiuretic hormone receptors and unmasks constitutive receptor signaling.Delineation of the structural basis for the activation properties of the dopamine D1 receptor subtypes.Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region.Refolding of G protein alpha subunits from inclusion bodies expressed in Escherichia coli.The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling.A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist.Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74.Lipid protein interactions couple protonation to conformation in a conserved cytosolic domain of G protein-coupled receptors.Simplified modeling approach suggests structural mechanisms for constitutive activation of the C5a receptor.Light-induced reorganization of phospholipids in rod disc membranes.Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling.The biologically crucial C terminus of cholecystokinin and the non-peptide agonist SR-146,131 share a common binding site in the human CCK1 receptor. Evidence for a crucial role of Met-121 in the activation process.
P2860
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P2860
The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
The activation process of the ...... f a highly conserved aspartate
@ast
The activation process of the ...... f a highly conserved aspartate
@en
type
label
The activation process of the ...... f a highly conserved aspartate
@ast
The activation process of the ...... f a highly conserved aspartate
@en
prefLabel
The activation process of the ...... f a highly conserved aspartate
@ast
The activation process of the ...... f a highly conserved aspartate
@en
P2093
P2860
P356
P1476
The activation process of the ...... f a highly conserved aspartate
@en
P2093
Cotecchia S
De Benedetti PG
P2860
P304
P356
10.1073/PNAS.94.3.808
P407
P577
1997-02-01T00:00:00Z