A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.
about
SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathwaysCNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5.Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.Anticancer therapeutic potential of Mn porphyrin/ascorbate systemNovel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.Radiation induces aerobic glycolysis through reactive oxygen species.A novel redox regulator, MnTnBuOE-2-PyP5+, enhances normal hematopoietic stem/progenitor cell function.Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia.Simple biological systems for assessing the activity of superoxide dismutase mimics.Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.Catalytic antioxidant therapy by metallodrugs: lessons from metallocorroles.Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin.Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin.Mn porphyrins as novel molecular magnetic resonance imaging contrast agents.Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment.Potential for a novel manganese porphyrin compound as adjuvant canine lymphoma therapy.A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.Detailed mechanism of the autoxidation of N-hydroxyurea catalyzed by a superoxide dismutase mimic Mn(III) porphyrin: formation of the nitrosylated Mn(II) porphyrin as an intermediate.Depletion of the cellular antioxidant system contributes to tenofovir disoproxil fumarate - induced mitochondrial damage and increased oxido-nitrosative stress in the kidney.Potential Therapeutic Applications of MnSODs and SOD-Mimetics.Differential Effects of Superoxide Dismutase Mimetics after Mechanical Overload of Articular Cartilage.Differences in Reperfusion-Induced Mitochondrial Oxidative Stress and Cell Death Between Hippocampal CA1 and CA3 Subfields Are Due to the Mitochondrial Thioredoxin System.Radiation-mediated tumor growth inhibition is significantly enhanced with redox-active compounds that cycle with ascorbate.Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues.Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning.Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation.
P2860
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P2860
A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
A new SOD mimic, Mn(III) ortho ...... pophilicity with low toxicity.
@ast
A new SOD mimic, Mn(III) ortho ...... pophilicity with low toxicity.
@en
type
label
A new SOD mimic, Mn(III) ortho ...... pophilicity with low toxicity.
@ast
A new SOD mimic, Mn(III) ortho ...... pophilicity with low toxicity.
@en
prefLabel
A new SOD mimic, Mn(III) ortho ...... pophilicity with low toxicity.
@ast
A new SOD mimic, Mn(III) ortho ...... pophilicity with low toxicity.
@en
P2093
P2860
P1476
A new SOD mimic, Mn(III) ortho ...... pophilicity with low toxicity.
@en
P2093
Alice M Li
Artak Tovmasyan
David S Warner
Edith B Gralla
Huaxin Sheng
Ines Batinic-Haberle
Ivan Spasojevic
Ludmil Benov
Miaomiao Lu
Zrinka Rajic
P2860
P304
P356
10.1016/J.FREERADBIOMED.2012.02.006
P577
2012-02-13T00:00:00Z