Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.
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SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathwaysMn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathwaysSupraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance.Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhageSpinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive toleranceSuperoxide dismutase mimics: chemistry, pharmacology, and therapeutic potentialNADPH-oxidase 2 activation promotes opioid-induced antinociceptive tolerance in mice.Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.Manganese(III) complexes of bis(hydroxyphenyl)dipyrromethenes are potent orally active peroxynitrite scavengers.Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia.Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death.Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimicsA new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumorReactive nitroxidative species and nociceptive processing: determining the roles for nitric oxide, superoxide, and peroxynitrite in pain.Roles of reactive oxygen and nitrogen species in painDesign, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.Morphine as a Potential Oxidative Stress-Causing Agent.Therapeutic potential of peroxynitrite decomposition catalysts: a patent review.Catalytic antioxidant therapy by metallodrugs: lessons from metallocorroles.Nitroxidative Signaling Mechanisms in Pathological Pain.NMDA-receptor activation and nitroxidative regulation of the glutamatergic pathway during nociceptive processing.Retooling manganese(III) porphyrin-based peroxynitrite decomposition catalysts for selectivity and oral activity: a potential new strategy for treating chronic pain.Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells.A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance.High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coliThermal stability of the prototypical Mn porphyrin-based superoxide dismutase mimic and potent oxidative-stress redox modulator Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride, MnTE-2-PyP(5+).Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation.
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Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 17 October 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Lipophilicity is a critical pa ...... roxynitrite-mediated pathways.
@en
Lipophilicity is a critical pa ...... roxynitrite-mediated pathways.
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type
label
Lipophilicity is a critical pa ...... roxynitrite-mediated pathways.
@en
Lipophilicity is a critical pa ...... roxynitrite-mediated pathways.
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prefLabel
Lipophilicity is a critical pa ...... roxynitrite-mediated pathways.
@en
Lipophilicity is a critical pa ...... roxynitrite-mediated pathways.
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P2093
P2860
P1476
Lipophilicity is a critical pa ...... roxynitrite-mediated pathways.
@en
P2093
Daniela Salvemini
Ines Batinić-Haberle
Ivan Spasojević
Júlio S Rebouças
Michael M Ndengele
P2860
P304
P356
10.1016/J.FREERADBIOMED.2008.09.037
P577
2008-10-17T00:00:00Z