The ubiquitin system: pathogenesis of human diseases and drug targeting.
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Identification, analysis, and prediction of protein ubiquitination sitesJohanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testingProteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processesConformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signalingCrystal structure of the ubiquitin-like small archaeal modifier protein 2 fromHaloferax volcaniiRegulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteinsA BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responsesThe Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's DiseaseDeficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)A human polymorphism affects NEDD4L subcellular targeting by leading to two isoforms that contain or lack a C2 domainMembrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathwaysDifferential tissue-specific protein markers of vaginal carcinoma.Usa1 protein facilitates substrate ubiquitylation through two separate domainsFunctional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport.Ubiquitination acutely regulates presynaptic neurotransmitter release in mammalian neuronsUp-regulation of beta-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cellsQuantitative proteomic identification of the BRCA1 ubiquitination substrates.Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation.A genome-scale CRISPR-Cas9 screening method for protein stability reveals novel regulators of Cdc25ATrafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts?The role of hypoxia inducible factor-1 in cell metabolism--a possible target in cancer therapy.An Internal Standard-Assisted Synthesis and Degradation Proteomic Approach Reveals the Potential Linkage between VPS4B Depletion and Activation of Fatty Acid β-Oxidation in Breast Cancer Cells.Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism.Pentosidine accumulation in human oocytes and their correlation to age-related apoptosisE3 ubiquitin ligase Pub1 is implicated in endocytosis of a GPI-anchored protein Ecm33 in fission yeast.Nonenzymatic ubiquitylation.Necroptosis, necrostatins and tissue injury.Mitosis-targeted anti-cancer therapies: where they stand.E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis.Assembly of the 20S proteasome.Use of zebrafish in chemical biology and drug discovery.Deubiquitinases and the new therapeutic opportunities offered to cancer.The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.Post-Translational Modification Profiling-Functional Proteomics for the Analysis of Immune Regulation.Downregulation of ubiquitin-specific protease 14 (USP14) inhibits breast cancer cell proliferation and metastasis, but promotes apoptosis.Post-translational modification profiling - A novel tool for mapping the protein modification landscape in cancer.Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system.Downregulation of ubiquitin level via knockdown of polyubiquitin gene Ubb as potential cancer therapeutic intervention.Persistent stimulation with interleukin-17 desensitizes cells through SCFβ-TrCP-mediated degradation of Act1.Analysis of intracellular substrates and products of thimet oligopeptidase in human embryonic kidney 293 cells.
P2860
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P2860
The ubiquitin system: pathogenesis of human diseases and drug targeting.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The ubiquitin system: pathogenesis of human diseases and drug targeting.
@ast
The ubiquitin system: pathogenesis of human diseases and drug targeting.
@en
type
label
The ubiquitin system: pathogenesis of human diseases and drug targeting.
@ast
The ubiquitin system: pathogenesis of human diseases and drug targeting.
@en
prefLabel
The ubiquitin system: pathogenesis of human diseases and drug targeting.
@ast
The ubiquitin system: pathogenesis of human diseases and drug targeting.
@en
P1476
The ubiquitin system: pathogenesis of human diseases and drug targeting.
@en
P2093
Alan L Schwartz
P356
10.1016/J.BBAMCR.2004.09.018
P407
P577
2004-11-01T00:00:00Z