Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. - Wikidata - wikimedia - TriplyDB

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism.

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism.

http://www.wikidata.org/entity/Q36642707

about

Cysteine-based regulation of the CUL3 adaptor protein Keap1 Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications Hormesis: Decoding Two Sides of the Same Coin Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics Antioxidant responses and cellular adjustments to oxidative stress Mechanisms of drug-induced liver injury Regulation of Nrf2-Mediated Phase II Detoxification and Anti-oxidant Genes The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response Structural analysis of the complex of Keap1 with a prothymosin α peptide Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1 Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates Stress-activated cap'n'collar transcription factors in aging and human disease CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2 Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system A novel mechanism for cytoprotection against hypoxic injury: δ-opioid receptor-mediated increase in Nrf2 translocation Basic principles and emerging concepts in the redox control of transcription factors p62 links autophagy and Nrf2 signaling Cytoprotection "gone astray": Nrf2 and its role in cancer Mitochondria and reactive oxygen species: physiology and pathophysiology The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System Prospective type 1 and type 2 disulfides of Keap1 protein.Nrf2: friend or foe for chemoprevention?An internal ribosomal entry site mediates redox-sensitive translation of Nrf2.Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes.Oxidative stress and inflammation modulate Rev-erbα signaling in the neonatal lung and affect circadian rhythmicity.Noblesse oblige: NRF2 functions in the airways.

P2860

Q24629359-5F60371D-2786-4775-A858-175E4BFE56E1 Q24652502-D6BB9D6B-EB0F-4CE0-B30D-6566D44520D3 Q24655442-C66DC518-13AA-4290-93E0-623B412E9624 Q26747249-9550E4A4-494C-4182-BE47-FAFED119102E Q26747274-ED0F7286-EC8B-4645-9E55-9B8703009646 Q26773354-0D9CED55-0B09-4DC6-9BD8-77BE917E99B8 Q26774916-A5D3BA54-7FF9-4B06-BE14-DBAE8E07B67D Q26778356-7FD6D558-BEE4-45FB-B030-D6704445B858 Q26778368-BB0CD4BA-28C3-4C10-8123-00538E2E3B22 Q26800229-F62E12CB-E46F-4335-8D7D-6CA4AEB40076 Q26998806-72CC9710-B897-4E6B-90E5-DB3D5281FFDD Q27000878-2449E53A-5880-4694-86FC-B097DE10FC61 Q27341433-32CB9B29-1648-4C50-A076-375BE71CF728 Q27647812-A28650ED-721B-4676-A9A9-4511A77F3757 Q27650252-149AF36D-6EEF-41E2-A2C6-235ECD4B8B02 Q27681060-BBA8C90F-C620-4F83-9695-351E2B0B5988 Q27682289-22CC333D-41C1-4157-9B3D-7E03F956AA9A Q27684072-6EE34A6B-1A35-467C-9E89-F7B96896D7C1 Q28085561-254CD616-BCBD-46A6-BC62-F3BAA6DD8EBE Q28384232-00889A62-9E09-4607-8E8B-633E88F776F0 Q28384271-80A403DC-9BE5-4233-B3F5-815F97F030AC Q28384783-DE9A085A-EAFE-423E-8B01-6C087A61C177 Q28384997-3C7617F8-174D-4D7A-BDF3-6C619F86DCDE Q28385517-40CA3933-E3DF-458D-B631-1C46D8EB0403 Q28386244-50623E4C-4835-4973-ABD3-319F0A758B6C Q28386313-319DE27E-1E37-4439-B585-31F71094CA54 Q28389419-289028AB-D8F6-413A-88E1-9673F6219CAA Q28390721-CF5E6405-E07E-4167-B14C-53442BECB06A Q28391506-C6D29943-F4EB-4965-949A-3EA30857B466 Q28392820-FFB524E0-DFDF-42DA-A97A-93E6E08D1831 Q28393784-C6148060-4BFD-496D-A009-80EE84A84E5E Q28397259-EB993B25-F2EC-4AED-A5BB-F6EB7352B4D1 Q28755952-6DB7B719-2F29-428A-9C72-2EC7F52C23B4 Q28817936-2778761F-2C15-4FE1-9443-0A2C7F5CE059 Q30371642-40A01B0E-E990-4336-8F8E-7C1EFF02E097 Q33575690-34936869-BFC1-4F2E-8AC9-53DEFF02EE0A Q33633725-1E3AFFA9-84ED-4749-9CB6-BEFE95DFAD4A Q33665347-F8BC6194-011B-40FB-9283-A2F8F6ADE4FA Q33722924-6FFB3DCD-5EBD-4EC3-9D8C-9E3D2C3CB1F1 Q33799768-1595BC50-3B4E-444A-A3B7-BC0716FB2CF7

P2860

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism.

http://www.wikidata.org/entity/Q36642707

description

2006 nî lūn-bûn

@nan

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

2006年论文

@zh

2006年论文

@zh-cn

name

Two-site substrate recognition ...... : a hinge and latch mechanism.

@ast

Two-site substrate recognition ...... : a hinge and latch mechanism.

@en

type

label

Two-site substrate recognition ...... : a hinge and latch mechanism.

@ast

Two-site substrate recognition ...... : a hinge and latch mechanism.

@en

prefLabel

Two-site substrate recognition ...... : a hinge and latch mechanism.

@ast

Two-site substrate recognition ...... : a hinge and latch mechanism.

@en

P1433

Q36642707-F6403F43-A8A3-4E77-BA65-655C4F13DD31

P1476

Q36642707-B9C0A867-E132-4D39-9A1B-7B56FA0B931D

P2093

Q36642707-1DD703DB-031A-4B90-BDEB-CB3E04767316

Q36642707-86FA95AC-D52F-4B8C-B63B-059AF6E18A8C

Q36642707-F751ADE8-2B85-4C2D-9B4F-B46C0078D254

Q36642707-FDDD14AA-6546-44EF-9721-AD4437CC0BC9

P2860

Q36642707-02AD0C1C-0B29-4E54-A69B-ED05BEF62094

Q36642707-0B0AE44E-9BD4-4CAC-B6CC-6E4D6085B2D9

Q36642707-0BFC781F-B617-4C52-926B-B78B989A3FA9

Q36642707-17A7477B-CE54-4801-8952-5DDC80BB730B

Q36642707-2416B123-69E2-4811-9BE8-F8DCD7A50CD7

Q36642707-2689160F-353A-4035-ADE5-701D017BDB05

Q36642707-29A6EB15-5E0F-4FCA-938A-D8E8B319A822

Q36642707-2A880337-1388-4E6D-86D2-567A8227EF63

Q36642707-2CC37C0B-8460-47A4-ACD3-475190EA9B74

Q36642707-2E27108D-8FB1-4321-A490-1CEFF78B446F

P304

Q36642707-08DADCC8-4F18-4FDA-99DD-D3CB822E54AC

P31

Q36642707-4817FB45-22F0-47FE-A4E9-0FABC192AE09

P356

Q36642707-D1F9F8CC-259D-4F6D-BADE-47D0428A3481

P433

Q36642707-49845403-2777-40EE-B06E-F3D374697339

P478

Q36642707-4D165964-D1E9-4079-9AD5-79B9B61B025C

P577

Q36642707-9E6F468A-F811-407B-8EF8-CAE547D23CF5

P698

Q36642707-6A2D9E73-A838-454F-9470-5B0900081558

P356

P1433

Biological Chemistry

P1476

Two-site substrate recognition ...... : a hinge and latch mechanism.

@en

P2093

Akira Kobayashi

http://www.w3.org/2001/XMLSchema#string

Fumiki Katsuoka

http://www.w3.org/2001/XMLSchema#string

Kit I Tong

http://www.w3.org/2001/XMLSchema#string

Masayuki Yamamoto

http://www.w3.org/2001/XMLSchema#string

P2860

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Sequence and structural analysis of BTB domain proteins

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

The ubiquitin system

P304

1311-1320

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1515/BC.2006.164

http://www.w3.org/2001/XMLSchema#string

P433

10-11

http://www.w3.org/2001/XMLSchema#string

P478

387

http://www.w3.org/2001/XMLSchema#string

P577

2006-10-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

17081101

http://www.w3.org/2001/XMLSchema#string