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Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT-Part I: Program Implementation and Lessons LearnedA multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessmentInhalation exposure to carbon nanotubes (CNT) and carbon nanofibers (CNF): methodology and dosimetryAdvancing human health risk assessment: integrating recent advisory committee recommendationsIPCS framework for analyzing the relevance of a noncancer mode of action for humansToxicity testing in the 21st century: a vision and a strategyAssessing the relevance of in vitro studies in nanotoxicology by examining correlations between in vitro and in vivo dataAssessment of Cr(VI)-induced cytotoxicity and genotoxicity using high content analysisApproaches for assessing risks to sensitive populations: lessons learned from evaluating risks in the pediatric populationAtrazine and breast cancer: a framework assessment of the toxicological and epidemiological evidenceLife-stage-, sex-, and dose-dependent dietary toxicokinetics and relationship to toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D) in rats: implications for toxicity test dose selection, design, and interpretationAn F1-extended one-generation reproductive toxicity study in Crl:CD(SD) rats with 2,4-dichlorophenoxyacetic acidComment on Shvedova et al. (2016), "gender differences in murine pulmonary responses elicited by cellulose nanocrystals"Equivalent titanium dioxide nanoparticle deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammationDose response relationship in anti-stress gene regulatory networksThe acquisition and application of absorption, distribution, metabolism, and excretion (ADME) data in agricultural chemical safety assessments.Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data.Creating context for the use of DNA adduct data in cancer risk assessment: I. Data organization.Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to α2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes.Organotypic liver culture models: meeting current challenges in toxicity testing.Extreme sensitivity and the practical implications of risk assessment thresholds.Issues in the design and interpretation of chronic toxicity and carcinogenicity studies in rodents: approaches to dose selection.Does physical exercise modify antioxidant requirements?Can case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?".A chronic reference value for 1,3-butadiene based on an updated noncancer toxicity assessment.Application of a novel integrated toxicity testing strategy incorporating "3R" principles of animal research to evaluate the safety of a new agrochemical sulfoxaflor.The perpetuation of the misconception that rats receive a 3-5 times lower lung tissue dose than humans at the same ozone concentration.Risk assessments for chronic exposure of children and prospective parents to ethylbenzene (CAS No. 100-41-4).International regulatory requirements for genotoxicity testing for pharmaceuticals used in human medicine, and their impurities and metabolites.Validation of Bioreactor and Human-on-a-Chip Devices for Chemical Safety Assessment.Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound.Multi-dose-route, multi-species pharmacokinetic models for manganese and their use in risk assessment.Concentration- and time-dependent effects of the synthetic estrogen, 17alpha-ethinylestradiol, on reproductive capabilities of the zebrafish, Danio rerio.Nanobarcoded superparamagnetic iron oxide nanoparticles for nanomedicine: Quantitative studies of cell-nanoparticle interactions by scanning image cytometry.Systems biology and mode of action based risk assessment.Derivation of PM10 size-selected human equivalent concentrations of inhaled nickel based on cancer and non-cancer effects on the respiratory tract.Three-dimensional co-culture of human hepatocytes and mesenchymal stem cells: improved functionality in long-term bioreactor cultures.Risk Assessment and Risk Minimization in Nanomedicine: A Need for Predictive, Alternative, and 3Rs Strategies.Toxicology in the drug discovery and development process.Toxicogenomics for transcription factor-governed molecular pathways: moving on to roles beyond classification and prediction
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Dose-dependent transitions in mechanisms of toxicity.
@ast
Dose-dependent transitions in mechanisms of toxicity.
@en
type
label
Dose-dependent transitions in mechanisms of toxicity.
@ast
Dose-dependent transitions in mechanisms of toxicity.
@en
prefLabel
Dose-dependent transitions in mechanisms of toxicity.
@ast
Dose-dependent transitions in mechanisms of toxicity.
@en
P2093
P1476
Dose-dependent transitions in mechanisms of toxicity.
@en
P2093
Dale Hattis
David C Dorman
David W Gaylor
James A Swenberg
James S Bus
John M Rogers
Kendall Wallace
Matthew S Bogdanffy
Nancy G Doerrer
R Woodrow Setzer
P304
P356
10.1016/J.TAAP.2004.06.019
P577
2004-12-01T00:00:00Z