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Dose-dependent transitions in mechanisms of toxicity: case studies.

Dose-dependent transitions in mechanisms of toxicity: case studies.

http://www.wikidata.org/entity/Q35975278

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Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT-Part I: Program Implementation and Lessons Learned Advancing human health risk assessment: integrating recent advisory committee recommendations Toxicity testing in the 21st century: a vision and a strategy Atrazine and breast cancer: a framework assessment of the toxicological and epidemiological evidence Life-stage-, sex-, and dose-dependent dietary toxicokinetics and relationship to toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D) in rats: implications for toxicity test dose selection, design, and interpretation Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans Dose response relationship in anti-stress gene regulatory networks Application of the U.S. EPA mode of action Framework for purposes of guiding future research: a case study involving the oral carcinogenicity of hexavalent chromium Linking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure.The acquisition and application of absorption, distribution, metabolism, and excretion (ADME) data in agricultural chemical safety assessments.BMDExpress: a software tool for the benchmark dose analyses of genomic data.Creating context for the use of DNA adduct data in cancer risk assessment: I. Data organization.Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to α2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes.Cadmium, environmental exposure, and health outcomes Toxicity testing in the 21st century: using the new toxicity testing paradigm to create a taxonomy of adverse effects.An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride.Organotypic liver culture models: meeting current challenges in toxicity testing.Issues in the design and interpretation of chronic toxicity and carcinogenicity studies in rodents: approaches to dose selection.Approaches for applications of physiologically based pharmacokinetic models in risk assessment.Can case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?".A chronic reference value for 1,3-butadiene based on an updated noncancer toxicity assessment.A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens.Application of a novel integrated toxicity testing strategy incorporating "3R" principles of animal research to evaluate the safety of a new agrochemical sulfoxaflor.Risk assessments for chronic exposure of children and prospective parents to ethylbenzene (CAS No. 100-41-4).Linear-No-Threshold Default Assumptions for Noncancer and Nongenotoxic Cancer Risks: A Mathematical and Biological Critique.International regulatory requirements for genotoxicity testing for pharmaceuticals used in human medicine, and their impurities and metabolites.Development of toxicity values and exposure estimates for tetrabromobisphenol A: application in a margin of exposure assessment.Dose- and time-dependent changes in tissue levels of tetrabromobisphenol A (TBBPA) and its sulfate and glucuronide conjugates following repeated administration to female Wistar Han Rats.Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound.Multi-dose-route, multi-species pharmacokinetic models for manganese and their use in risk assessment.Guidance for submission for food additive evaluations Toxicology in the drug discovery and development process.IPCS framework for analyzing the relevance of a cancer mode of action for humans.Cadmium, environmental exposure, and health outcomes.Toxicogenomics for transcription factor-governed molecular pathways: moving on to roles beyond classification and prediction Biologically Motivated Approaches to Extrapolation from High to Low Doses and the Advent of Systems Biology: The Road to Toxicological Safety Assessment Lung Cancer Risk and Low (≤50 μg/L) Drinking Water Arsenic Levels for US Counties (2009⁻2013)-A Negative Association

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Dose-dependent transitions in mechanisms of toxicity: case studies.

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J.TAAP.2004.06.027

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Toxicology and Applied Pharmacology

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David W Gaylor

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