Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection
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Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activitySurvivin monomer plays an essential role in apoptosis regulationHsp60 regulation of tumor cell apoptosisDifferential PKA activation and AKAP association determines cell fate in cancer cellsThreonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitroCombinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90Survivin - The inconvenient IAPSurvivin - biology and potential as a therapeutic target in oncologyTargeting survivin in cancerSurvivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasionMitochondrial cAMP signalingTargeting survivin in cancer therapyMitochondria and FOXO3: breath or dieLoss of survivin in the prostate epithelium impedes carcinogenesis in a mouse model of prostate adenocarcinomaTransforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cellsProteomic analysis of HuH-7 cells harboring in vitro-transcribed full-length hepatitis C virus 1b RNA.HPV16 E7-dependent transformation activates NHE1 through a PKA-RhoA-induced inhibition of p38alpha.IAP regulation of metastasis.Survivin mutant protects differentiated dopaminergic SK-N-SH cells against oxidative stress.Identification of a novel TGFβ/PKA signaling transduceome in mediating control of cell survival and metastasis in colon cancer.Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cellsProstate cancer regulatory networksAkt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.Down-regulation of the antisense mitochondrial non-coding RNAs (ncRNAs) is a unique vulnerability of cancer cells and a potential target for cancer therapy.YM155 induces EGFR suppression in pancreatic cancer cells.cAMP initiates early phase neuron-like morphology changes and late phase neural differentiation in mesenchymal stem cellsThe detergent-soluble cytoplasmic pool of survivin suppresses anoikis and its expression is associated with metastatic disease of human colon cancerDevelopmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein.Nuclear survivin and its relationship to DNA damage repair genes in non-small cell lung cancer investigated using tissue arrayFunction of survivin in trophoblastic cells of the placenta.Apoptotic cell signaling in cancer progression and therapyAkt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer.Elevated levels of uterine anti-apoptotic signaling may activate NFKB and potentially confer resistance to caspase 3-mediated apoptotic cell death during pregnancy in mice.Histone deacetylase inhibitor belinostat represses survivin expression through reactivation of transforming growth factor beta (TGFbeta) receptor II leading to cancer cell death.Survivin and IAP proteins in cell-death mechanismsMicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancerSerum Survivin Levels and Outcome of Chemotherapy in Patients with Malignant Mesothelioma.Survivin contributes to DNA repair by homologous recombination in breast cancer cells.Cell survival and metastasis regulation by Akt signaling in colorectal cancer
P2860
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P2860
Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection
@ast
Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection
@en
type
label
Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection
@ast
Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection
@en
prefLabel
Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection
@ast
Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection
@en
P2093
P2860
P1433
P1476
Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection
@en
P2093
Dario C Altieri
Takehiko Dohi
P2860
P356
10.1016/J.MOLCEL.2007.06.004
P577
2007-07-01T00:00:00Z