Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant
about
Analyzing the roles of multi-functional proteins in cells: The case of arrestins and GRKsHow genetic errors in GPCRs affect their function: Possible therapeutic strategiesIdentification of receptor binding-induced conformational changes in non-visual arrestins.Arrestins regulate cell spreading and motility via focal adhesion dynamicsGPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014.Manipulation of very few receptor discriminator residues greatly enhances receptor specificity of non-visual arrestinsConformation of receptor-bound visual arrestin.Serine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling.Engineering visual arrestin-1 with special functional characteristicsCritical role of the central 139-loop in stability and binding selectivity of arrestin-1.The β-Arrestins: Multifunctional Regulators of G Protein-coupled ReceptorsJNK3 enzyme binding to arrestin-3 differentially affects the recruitment of upstream mitogen-activated protein (MAP) kinase kinasesArrestin-3 binds c-Jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding.Synthetic biology with surgical precision: targeted reengineering of signaling proteins.Structural determinants of arrestin functionsExtensive shape shifting underlies functional versatility of arrestins.Overview of different mechanisms of arrestin-mediated signaling.Peptide mini-scaffold facilitates JNK3 activation in cellsMutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypesThe Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.Carboxyl terminus-truncated α1D-adrenoceptors inhibit the ERK pathway.Arrestin-3-Dependent Activation of c-Jun N-Terminal Kinases (JNKs).Targeting individual GPCRs with redesigned nonvisual arrestins.Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains.Arrestins in apoptosis.Therapeutic potential of small molecules and engineered proteins.Arrestin-dependent activation of JNK family kinasesDifferential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors.Structural basis of arrestin-3 activation and signaling.Molecular Mechanisms of GPCR Signaling: A Structural Perspective.Heterologous phosphorylation-induced formation of a stability lock permits regulation of inactive receptors by β-arrestins.Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of GPCRs.A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis.
P2860
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P2860
Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Silent scaffolds: inhibition O ...... ant-negative arrestin-3 mutant
@ast
Silent scaffolds: inhibition O ...... ant-negative arrestin-3 mutant
@en
type
label
Silent scaffolds: inhibition O ...... ant-negative arrestin-3 mutant
@ast
Silent scaffolds: inhibition O ...... ant-negative arrestin-3 mutant
@en
prefLabel
Silent scaffolds: inhibition O ...... ant-negative arrestin-3 mutant
@ast
Silent scaffolds: inhibition O ...... ant-negative arrestin-3 mutant
@en
P2093
P2860
P356
P1476
Silent scaffolds: inhibition O ...... ant-negative arrestin-3 mutant
@en
P2093
Eugenia V Gurevich
Luis E Gimenez
Maria C Palazzo
Maya Breitman
Seunghyi Kook
P2860
P304
19653-19664
P356
10.1074/JBC.M112.358192
P407
P577
2012-04-20T00:00:00Z