DNA damage induces Chk1-dependent centrosome amplification. - Wikidata - wikimedia - TriplyDB

DNA damage induces Chk1-dependent centrosome amplification.

DNA damage induces Chk1-dependent centrosome amplification.

http://www.wikidata.org/entity/Q36029906

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Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy A novel role of human holliday junction resolvase GEN1 in the maintenance of centrosome integrity Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization Emergence of micronuclei and their effects on the fate of cells under replication stress Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach.Overexpression of EVI1 interferes with cytokinesis and leads to accumulation of cells with supernumerary centrosomes in G0/1 phase.Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells.Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification.CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response.Beclin 1 and UVRAG confer protection from radiation-induced DNA damage and maintain centrosome stability in colorectal cancer cells Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair.The fate of chrysotile-induced multipolar mitosis and aneuploid population in cultured lung cancer cells.Centrosomes as signalling centres.Link between DNA damage and centriole disengagement/reduplication in untransformed human cells.Depletion of the oncoprotein Bcl-3 induces centrosome amplification and aneuploidy in cancer cells.A centrosome-autonomous signal that involves centriole disengagement permits centrosome duplication in G2 phase after DNA damage.Weighted frequent gene co-expression network mining to identify genes involved in genome stability.Cdk5rap2 exposes the centrosomal root of microcephaly syndromes.Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis.Steroidogenic factor 1 (NR5A1) maintains centrosome homeostasis in steroidogenic cells by restricting centrosomal DNA-dependent protein kinase activation Promoter hijack reveals pericentrin functions in mitosis and the DNA damage response.A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells.Evidence for regulation of mitotic progression through temporal phosphorylation and dephosphorylation of CK2alpha.Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification.Mechanisms of metal-induced centrosome amplification.Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis.Centrosomes and cilia in human disease.Such small hands: the roles of centrins/caltractins in the centriole and in genome maintenance.Centrosome amplification, chromosomal instability and cancer: mechanistic, clinical and therapeutic issues.PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage.Ionizing radiation increases primary cilia incidence and induces multiciliation in C2C12 myoblasts.BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1 DNA damage-induced centrosome amplification occurs via excessive formation of centriolar satellites.Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint.MCPH1/BRIT1 limits ionizing radiation-induced centrosome amplification.The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction.Orc1 controls centriole and centrosome copy number in human cells.

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P2860

DNA damage induces Chk1-dependent centrosome amplification.

http://www.wikidata.org/entity/Q36029906

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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name

DNA damage induces Chk1-dependent centrosome amplification.

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DNA damage induces Chk1-dependent centrosome amplification.

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DNA damage induces Chk1-dependent centrosome amplification.

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DNA damage induces Chk1-dependent centrosome amplification.

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DNA damage induces Chk1-dependent centrosome amplification.

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DNA damage induces Chk1-dependent centrosome amplification.

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SJ.EMBOR.7400962

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DNA damage induces Chk1-dependent centrosome amplification

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Andreas Merdes

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David Gillespie

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George Zachos

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Helen Dodson

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Lorraine Cuffe

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Mark Walker

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P2860

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

Centrosome amplification drives chromosomal instability in breast tumor development.

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

Assembly of centrosomal proteins and microtubule organization depends on PCM-1

NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

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603-609

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scholarly article

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10.1038/SJ.EMBOR.7400962

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6

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8

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Ciaran G Morrison

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2007-04-27T00:00:00Z

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6360728

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17468739

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2002539

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