Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways - Wikidata - wikimedia - TriplyDB

Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways

Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways

http://www.wikidata.org/entity/Q36030524

about

Phosphoinositide kinase signaling controls ER-PM cross-talk.Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress Sphingolipid biosynthesis upregulation by TOR complex 2-Ypk1 signaling during yeast adaptive response to acetic acid stress Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1 The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis.Fimbrin phosphorylation by metaphase Cdk1 regulates actin cable dynamics in budding yeast.Yeast protein phosphatase 2A-Cdc55 regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 chromatin recruitment.Direct and Indirect Targeting of PP2A by Conserved Bacterial Type-III Effector Proteins Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae.Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans Expression of the bacterial type III effector DspA/E in Saccharomyces cerevisiae down-regulates the sphingolipid biosynthetic pathway leading to growth arrest.Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis.TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids.Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells RNA-seq analysis of broiler liver transcriptome reveals novel responses to high ambient temperature.Rom2-dependent phosphorylation of Elo2 controls the abundance of very long-chain fatty acids.Control of Plasma Membrane Permeability by ABC Transporters.Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways.Depletion of yeast PDK1 orthologs triggers a stress-like transcriptional response.Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice Characterization of AnNce102 and its role in eisosome stability and sphingolipid biosynthesis.Airway reactivity and sphingolipids-implications for childhood asthma Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes Following the flux of long-chain bases through the sphingolipid pathway in vivo using mass spectrometry.Differential Phosphorylation Provides a Switch to Control How α-Arrestin Rod1 Down-regulates Mating Pheromone Response in Saccharomyces cerevisiae.Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.Fpk1/2 kinases regulate cellular sphingoid long-chain base abundance and alter cellular resistance to LCB elevation or depletion.Yeast as a model system for studying lipid homeostasis and function.Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae.Sphingolipid homeostasis in the endoplasmic reticulum and beyond.17q21 locus and ORMDL3: an increased risk for childhood asthma.The AvrE superfamily: ancestral type III effectors involved in suppression of pathogen-associated molecular pattern-triggered immunity.Orosomucoid, an acute response protein with multiple modulating activities.Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis.Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans.The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma.

P2860

Q27304793-FA64C820-8B9C-4E53-BB20-589C8C8EF051 Q27930785-1DF19816-2D83-4724-84BC-DFE7C7986367 Q27931435-9F263897-5713-49AE-9A7A-35F3EB8C7D9A Q27932351-8BD23F0A-254B-400B-967E-B6B4AF68A264 Q27933657-12CBC123-2F62-4E12-8004-D3C241C9FC91 Q27935105-25946E9A-93F9-45CE-BC26-661CB1D756B4 Q27937510-3436E550-9986-46CE-9B04-1ECD77475ED6 Q27939315-17174EAA-493D-4C4E-BF96-5E28AEABAD33 Q27939447-551FF824-B65F-4570-9BC6-995BB26F1AE9 Q28552199-C3DB930E-BB61-44CB-AB4D-5B14FEB1F413 Q33557346-3E46E20E-5EA3-4BCD-93C4-47499E0BE771 Q33918952-25F68701-9F4B-4AC2-90EE-F5216A7F8809 Q34073801-E2EE82F4-1D26-4291-B37A-4393CD13418B Q34338023-EF98FB82-12AC-4465-8154-AF6C5495A55F Q34440056-86937775-9E5F-4829-BA87-978D4989A8FE Q34614412-2DD0C7E7-0350-453C-AF3E-EE3B279C12C0 Q34801792-4ABF997C-5768-4E98-8201-6183CB54B103 Q34986547-20007C70-AF94-466E-BEE9-2D15BA0FFF11 Q35080312-1EBEE58B-FE19-48F6-873A-684332588020 Q35573342-7F0FB714-7078-4449-BDE4-72E2C185D72B Q35721719-8E02264C-F15F-47DE-9E72-862963DACA18 Q35782491-CC44D25C-34D9-4A88-9822-CC07FA9CF4B9 Q36058716-4CD83ECD-5D24-496E-99AD-8F0ECAEC2BF5 Q36113177-ACBECEE0-E99D-4585-9853-53AAFBCFA553 Q36163974-9C0ABF18-2183-4BED-9D7C-AA1150AAEE0E Q36348432-C3485CA3-AC12-4589-B21C-553AB1F356CB Q36505126-3FF1DF3B-BDD4-44C7-9F11-D6D47C47262A Q36843274-472E1B74-0B5D-48EB-A877-5DC5AE1F6289 Q36875629-F837CB33-BB50-403F-948C-33BF831B8F9E Q37638571-DB193DCF-E0B3-406E-BF52-328C52CF76FB Q37718309-26A8E8D8-4C35-4811-AFAA-A5795AEF6726 Q38028724-2AF1BE54-E8CC-4384-96EC-B802516F05C1 Q38034862-A6B1B3ED-6A23-4980-969B-CE95E26CC3DC Q38094869-ED21B384-8ED3-4C97-AC79-00763A870930 Q38156023-94A16F40-D118-442E-9D7D-9EB142E5187B Q38339915-1817B809-E12D-47AD-BFC1-FFE0187DADC7 Q38364856-3BA05A06-AAC9-4A44-8FDD-273ED27AD53C Q38690945-8864C669-05C2-476A-829E-9A9E5C854530 Q38752381-0D79497F-8A16-491E-AB87-D4FFCA720455 Q38771128-8550795C-A850-4532-B0CE-9BF04F08F211

P2860

Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways

http://www.wikidata.org/entity/Q36030524

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

Orm protein phosphoregulation ...... kh-Ypk and Cdc55-PP2A pathways

@ast

Orm protein phosphoregulation ...... kh-Ypk and Cdc55-PP2A pathways

@en

type

label

Orm protein phosphoregulation ...... kh-Ypk and Cdc55-PP2A pathways

@ast

Orm protein phosphoregulation ...... kh-Ypk and Cdc55-PP2A pathways

@en

prefLabel

Orm protein phosphoregulation ...... kh-Ypk and Cdc55-PP2A pathways

@ast

Orm protein phosphoregulation ...... kh-Ypk and Cdc55-PP2A pathways

@en

P1433

Q36030524-6C0D3520-A858-4533-B6E1-E5DD10DB4E2A

P1476

Q36030524-D1F7F2BD-6830-4E44-B00A-594824770EA6

P2093

Q36030524-2A75CE1C-78B0-4F62-8158-3BCFE644B405

Q36030524-2FC8C31F-7C54-4C74-82EB-117FE041DC4B

Q36030524-5078EED8-7A55-41D7-87DA-862E65F40539

Q36030524-50876BC3-D82A-4640-BB5A-B58AD48734F5

Q36030524-DC560928-83E0-4B72-80A2-CB8A53F1E21B

Q36030524-ECA36DB1-D055-4B40-BB04-0E0D6758884D

Q36030524-F2918BC6-3CD8-44E4-A9DF-399CB96DAD8D

P2860

Q36030524-08BCF405-7C3B-4CDA-B743-A02479255C9B

Q36030524-11D2AD85-0310-4EB2-BE11-0F7D4D2B6AB4

Q36030524-133C1A17-6348-4D95-BC1F-07816BC62062

Q36030524-14EB0AF4-3AA8-48B0-88E3-637BB76DC1DB

Q36030524-14EC757D-BE83-4DC6-8454-7DD7D6A7A9A6

Q36030524-155DEFC5-DFCC-4E69-A2C7-6193A19629B5

Q36030524-2AD73563-A600-4874-9AD9-F6EF1B5D4A08

Q36030524-316BC2C6-8913-4149-8764-889946BDBFE4

Q36030524-3B3752A0-832A-4157-8870-408CB5ED2884

Q36030524-3CF246F3-4C8F-40F4-BBDD-205B59B83238

P304

Q36030524-7ECB4051-3C3C-460F-B96E-81B2471CCFEF

P31

Q36030524-FDCDD77D-5B95-43A0-9C70-B7E8A20C066C

P356

Q36030524-D14EB539-179D-4620-BEFB-E023ADC43D36

P433

Q36030524-75FE6166-88E5-4FDB-A13E-5D9024F4689B

P478

Q36030524-3D0C7761-6B2C-49C6-9C2E-8E80DD692B23

P50

Q36030524-5E3F8F7B-E6AB-4702-93F4-4BEF4F0D3C00

P577

Q36030524-7D3A985A-CC3C-425D-A58D-1C3216EF638A

P698

Q36030524-032CA252-1B5B-4F98-ACB2-E889A7A7057C

P932

Q36030524-FE187F6C-1F8C-449A-B21E-D0DCD7A4EE49

P356

MBC.E12-03-0209

P1433

Molecular Biology of the Cell

P1476

Orm protein phosphoregulation ...... kh-Ypk and Cdc55-PP2A pathways

@en

P2093

Chao Zhang

http://www.w3.org/2001/XMLSchema#string

Hiromu Takematsu

http://www.w3.org/2001/XMLSchema#string

Kevan M Shokat

http://www.w3.org/2001/XMLSchema#string

Yansong Miao

http://www.w3.org/2001/XMLSchema#string

Yasunori Kozutsumi

http://www.w3.org/2001/XMLSchema#string

Yidi Sun

http://www.w3.org/2001/XMLSchema#string

Yukari Yamane

http://www.w3.org/2001/XMLSchema#string

P2860

Orm family proteins mediate sphingolipid homeostasis

Lcb4p is a key regulator of ceramide synthesis from exogenous long chain sphingoid base in Saccharomyces cerevisiae.

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast.

Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2.

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.

Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene.

Pkh-kinases control eisosome assembly and organization.

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae.

Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast.

The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses.

P304

2388-2398

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1091/MBC.E12-03-0209

http://www.w3.org/2001/XMLSchema#string

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

23

http://www.w3.org/2001/XMLSchema#string

P50

P577

2012-04-25T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

22535525

http://www.w3.org/2001/XMLSchema#string

P932

3374756

http://www.w3.org/2001/XMLSchema#string