Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast
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Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylationIron, glucose and intrinsic factors alter sphingolipid composition as yeast cells enter stationary phase.The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.Rice ORMDL controls sphingolipid homeostasis affecting fertility resulting from abnormal pollen developmentSystematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis.TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids.Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cellsRom2-dependent phosphorylation of Elo2 controls the abundance of very long-chain fatty acids.Control of Plasma Membrane Permeability by ABC Transporters.Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathwaysAberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in miceFollowing the flux of long-chain bases through the sphingolipid pathway in vivo using mass spectrometry.An inducible ER-Golgi tether facilitates ceramide transport to alleviate lipotoxicitySphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses.Sphingolipid homeostasis in the endoplasmic reticulum and beyond.Assessment of crosstalks between the Snf1 kinase complex and sphingolipid metabolism in S. cerevisiae via systems biology approaches.The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma.Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells.Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesisORMDL proteins regulate ceramide levels during sterile inflammation.A novel Sit4 phosphatase complex is involved in the response to ceramide stress in yeast.The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT): effects of the small subunits and insights from bacterial mimics of human hLCB2a HSAN1 mutationsAccumulation of long-chain bases in yeast promotes their conversion to a long-chain base vinyl ether.Orm proteins integrate multiple signals to maintain sphingolipid homeostasis.The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1.Sphingolipid accumulation causes mitochondrial dysregulation and cell death.The metabolomic signature of Leber's hereditary optic neuropathy reveals endoplasmic reticulum stress.Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling.Sphingolipids activate the endoplasmic reticulum stress surveillance pathway.Inositol Depletion Induced by Acute Treatment of the Bipolar Disorder Drug Valproate Increases Levels of Phytosphingosine.pH homeostasis links the nutrient sensing PKA/TORC1/Sch9 ménage-à-trois to stress tolerance and longevity.Yeast lacking the amphiphysin family protein Rvs167 is sensitive to disruptions in sphingolipid levels.Endoplasmic reticulum-plasma membrane contact sites integrate sterol and phospholipid regulation.
P2860
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P2860
Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast
@ast
Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast
@en
type
label
Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast
@ast
Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast
@en
prefLabel
Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast
@ast
Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast
@en
P2093
P2860
P356
P1476
Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast
@en
P2093
Chunjuan Huang
Surendranath R Polu
P2860
P304
P356
10.1242/JCS.100578
P407
P577
2012-02-10T00:00:00Z