Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.
about
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genesCurrent strategies for mutation detection in phenotype-driven screens utilising next generation sequencingMouse Genome Informatics (MGI): reflecting on 25 yearsMouse Genome Database: From sequence to phenotypes and disease modelsHigh throughput sequencing approaches to mutation discovery in the mouseLoss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in miceSpontaneous 8bp Deletion in Nbeal2 Recapitulates the Gray Platelet Syndrome in MiceUnlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutationsCHD7 deficiency in "Looper", a new mouse model of CHARGE syndrome, results in ossicle malformation, otosclerosis and hearing impairmentGenome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental diseaseMutation in MRPS34 compromises protein synthesis and causes mitochondrial dysfunctionGenome-Wide Exome Analysis of Cmv5-Disparate Mouse Strains that Differ in Host Resistance to Murine Cytomegalovirus Infection.Two ENU-induced alleles of Atp2b2 cause deafness in mice.The old and new face of craniofacial research: How animal models inform human craniofacial genetic and clinical dataMutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production.High-resolution measurements of the multilayer ultra-structure of articular cartilage and their translational potential.Large-scale identification of chemically induced mutations in Drosophila melanogaster.Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes.The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease.ENU-induced phenovariance in mice: inferences from 587 mutations.Mouse ENU Mutagenesis to Understand Immunity to Infection: Methods, Selected Examples, and Perspectives.A mouse splice-site mutant and individuals with atypical chromosome 22q11.2 deletions demonstrate the crucial role for crkl in craniofacial and pharyngeal development.Real-time resolution of point mutations that cause phenovariance in mice.Characterization of ENU-induced Mutations in Red Blood Cell Structural Proteins.Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres.Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment.Simulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells.Genomic characterization of mutant laboratory mouse strains by exome sequencing and annotation lift-over.Reducing the search space for causal genetic variants with VASP.Delayed control of herpes simplex virus infection and impaired CD4(+) T-cell migration to the skin in mouse models of DOCK8 deficiencyVariant mapping and mutation discovery in inbred mice using next-generation sequencingReliably Detecting Clinically Important Variants Requires Both Combined Variant Calls and Optimized Filtering Strategies.Comparison of predicted and actual consequences of missense mutations.Can the impact of human genetic variations be predicted?B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.Going forward with genetics: recent technological advances and forward genetics in mice.Improvement of ENU Mutagenesis Efficiency Using Serial Injection and Mismatch Repair Deficiency Mice.Identification of mutations through dominant screening for obesity using C57BL/6 substrains
P2860
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P2860
Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Massively parallel sequencing ...... thousands of new mouse models.
@ast
Massively parallel sequencing ...... thousands of new mouse models.
@en
type
label
Massively parallel sequencing ...... thousands of new mouse models.
@ast
Massively parallel sequencing ...... thousands of new mouse models.
@en
prefLabel
Massively parallel sequencing ...... thousands of new mouse models.
@ast
Massively parallel sequencing ...... thousands of new mouse models.
@en
P2093
P2860
P50
P356
P1433
P1476
Massively parallel sequencing ...... thousands of new mouse models
@en
P2093
B Balakishnan
G Sjollema
S Winslade
P2860
P304
P356
10.1098/RSOB.120061
P577
2012-05-01T00:00:00Z