Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity.
about
Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich regionProtein phosphorylation cascades associated with methamphetamine-induced glial activation.mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4ERegulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivomTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cellsS6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathwayEnhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.Characterization of S6K2, a novel kinase homologous to S6K1p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytesAmino acids regulate skeletal muscle PHAS-I and p70 S6-kinase phosphorylation independently of insulinRibosomal protein S6 phosphorylation and function during late gestation liver development in the ratp70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BADBMAL1-dependent regulation of the mTOR signaling pathway delays agingTarget of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progressionNovel 5'TOPmRNAs regulated by ribosomal S6 kinase are important for cardiomyocyte development: S6 kinase suppression limits cardiac differentiation and promotes pluripotent cells toward a neural lineage.Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylationS6 phosphorylation-independent pathways regulate translation of 5'-terminal oligopyrimidine tract-containing mRNAs in differentiating hematopoietic cells.Partial restoration of cardiac function with ΔPDZ nNOS in aged mdx model of Duchenne cardiomyopathy.Farnesyltransferase inhibitor-induced regression of mammary tumors in TGF alpha and TGF alpha/neu transgenic mice correlates with inhibition of map kinase and p70s6 kinase phosphorylation.Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice.p70(S6K) controls selective mRNA translation during oocyte maturation and early embryogenesis in Xenopus laevis.mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin.Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylationmTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells.Cellular differences in protein synthesis regulate tissue homeostasis.Ribosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPDMolecular crosstalk between p70S6k and MAPK cell signaling pathways.Mitogenic and nutritional signals are transduced into translational efficiency of TOP mRNAs.A human class II MHC-derived peptide antagonizes phosphatidylinositol 3-kinase to block IL-2 signaling.Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells.The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression.Glucocorticoids and TNFalpha interact cooperatively to mediate sepsis-induced leucine resistance in skeletal muscle.The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALLIron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD1.Ribosomal proteins and colorectal cancerEmbryonic lethality of fortilin-null mutant mice by BMP-pathway overactivationA disputed evidence on obesity: comparison of the effects of Rcan2(-/-) and Rps6kb1(-/-) mutations on growth and body weight in C57BL/6J mice
P2860
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P2860
Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Targeted disruption of p70(s6k ...... sis and rapamycin sensitivity.
@ast
Targeted disruption of p70(s6k ...... sis and rapamycin sensitivity.
@en
type
label
Targeted disruption of p70(s6k ...... sis and rapamycin sensitivity.
@ast
Targeted disruption of p70(s6k ...... sis and rapamycin sensitivity.
@en
prefLabel
Targeted disruption of p70(s6k ...... sis and rapamycin sensitivity.
@ast
Targeted disruption of p70(s6k ...... sis and rapamycin sensitivity.
@en
P2093
P2860
P356
P1476
Targeted disruption of p70(s6k ...... sis and rapamycin sensitivity.
@en
P2093
E W Gelfand
G L Johnson
G M Keller
H Kawasome
P2860
P304
P356
10.1073/PNAS.95.9.5033
P407
P577
1998-04-01T00:00:00Z