Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
about
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4EProteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translationSignaling by target of rapamycin proteins in cell growth controlmTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cellsFunctional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translationS6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathwayUpdates of mTOR inhibitorsDual requirement for a newly identified phosphorylation site in p70s6kRAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeletonRegulation of global and specific mRNA translation by the mTOR signaling pathwayThe role and regulation of mTOR in T-lymphocyte functionmTORC1 signaling activates NRF1 to increase cellular proteasome levelsThe expanding role of mTOR in cancer cell growth and proliferationRiboTag analysis of actively translated mRNAs in Sertoli and Leydig cells in vivo.Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.TOR controls translation initiation and early G1 progression in yeastLa-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinaseExpression of the gene and processed pseudogenes encoding the human and rabbit translationally controlled tumour protein (TCTP)Characterization of S6K2, a novel kinase homologous to S6K1Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitroIdentification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytesInsulin inhibits glucocorticoid-stimulated L-type 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression by activation of the c-Jun N-terminal kinase pathwayRapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translationNerve growth factor specifically stimulates translation of eukaryotic elongation factor 1A-1 (eEF1A-1) mRNA by recruitment to polyribosomes in PC12 cellsHyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathwaysInsulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTOR) signalling is impaired by the presence of hydrogen peroxideInactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cellsRibosomal protein S6 phosphorylation and function during late gestation liver development in the ratThermal injury impairs cardiac protein synthesis and is associated with alterations in translation initiationInsulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activityExpression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophyRibosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis.Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathwayAmino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanismTarget of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progressionThe rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin.TOR signaling.cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.
P2860
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P2860
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
description
1994 nî lūn-bûn
@nan
1994 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
@ast
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
@en
type
label
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
@ast
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
@en
prefLabel
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
@ast
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
@en
P2093
P2860
P356
P1476
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
@en
P2093
P2860
P304
P356
10.1073/PNAS.91.10.4441
P407
P577
1994-05-01T00:00:00Z