Human POLB gene is mutated in high percentage of colorectal tumors. - Wikidata - wikimedia - TriplyDB

Human POLB gene is mutated in high percentage of colorectal tumors.

Human POLB gene is mutated in high percentage of colorectal tumors.

http://www.wikidata.org/entity/Q36078847

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MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA Gut Microbiota Imbalance and Base Excision Repair Dynamics in Colon Cancer Tumor-specific microsatellite instability: do distinct mechanisms underlie the MSI-L and EMAST phenotypes?DNA polymerase delta in DNA replication and genome maintenance The E295K Cancer Variant of Human Polymerase Favors the Mismatch Conformational Pathway during Nucleotide Selection DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair DNA polymerase β contains a functional nuclear localization signal at its N-terminus.The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.Irreversible inhibition of DNA polymerase β by small-molecule mimics of a DNA lesion A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated Variant Sequence context modulation of polycyclic aromatic hydrocarbon-induced mutagenesis.Single nucleotide polymorphisms within interferon signaling pathway genes are associated with colorectal cancer susceptibility and survival.Substrate-induced DNA polymerase β activation.Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase.Substrate-dependent millisecond domain motions in DNA polymerase β.Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.Synergistic Effects of an Irreversible DNA Polymerase Inhibitor and DNA Damaging Agents on HeLa Cells.Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks Transcriptional profiling reveals elevated Sox2 in DNA polymerase ß null mouse embryonic fibroblasts.Evidence-based Guidelines for Precision Risk Stratification-Based Screening (PRSBS) for Colorectal Cancer: Lessons learned from the US Armed Forces: Consensus and Future Directions.The structural location of DNA lesions in nucleosome core particles determines accessibility by base excision repair enzymes Site-specific Acetylation of Histone H3 Decreases Polymerase β Activity on Nucleosome Core Particles in Vitro Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity Catalytic effects of mutations of distant protein residues in human DNA polymerase β: theory and experiment.Substrate rescue of DNA polymerase β containing a catastrophic L22P mutation.Cellular roles of DNA polymerase beta.DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy.Base excision repair of oxidative DNA damage: from mechanism to disease.DNA polymerase β promoter mutations and transcriptional activity in esophageal squamous cell carcinoma.Genome instability caused by a germline mutation in the human DNA repair gene POLB.DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity.Role of Conformational Motions in Enzyme Function: Selected Methodologies and Case Studies.Base Excision Repair Variants in Cancer.

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P2860

Human POLB gene is mutated in high percentage of colorectal tumors.

http://www.wikidata.org/entity/Q36078847

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Human POLB gene is mutated in high percentage of colorectal tumors.

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Human POLB gene is mutated in high percentage of colorectal tumors.

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type

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Human POLB gene is mutated in high percentage of colorectal tumors.

@ast

Human POLB gene is mutated in high percentage of colorectal tumors.

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prefLabel

Human POLB gene is mutated in high percentage of colorectal tumors.

@ast

Human POLB gene is mutated in high percentage of colorectal tumors.

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JBC.M111.324947

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Journal of Biological Chemistry

P1476

Human POLB gene is mutated in high percentage of colorectal tumors.

@en

P2093

Antonia A Nemec

http://www.w3.org/2001/XMLSchema#string

Daniel Zelterman

http://www.w3.org/2001/XMLSchema#string

Drew L Murphy

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Joann B Sweasy

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Ka-wai Sun

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Katherine A Donigan

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Veronika Northrup

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Xiangyu Cong

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P2860

Instability and decay of the primary structure of DNA

Codon usage tabulated from international DNA sequence databases: status for the year 2000

Fast and effective prediction of microRNA/target duplexes

Hairpin structure within the 3'UTR of DNA polymerase beta mRNA acts as a post-transcriptional regulatory element and interacts with Hax-1

A variant of DNA polymerase beta acts as a dominant negative mutant

Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity

Prediction of mammalian microRNA targets

A method and server for predicting damaging missense mutations

The consensus coding sequences of human breast and colorectal cancers

DNA polymerase beta expression differences in selected human tumors and cell lines

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10.1074/JBC.M111.324947

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28

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287

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3390656

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