Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation. - Wikidata - wikimedia - TriplyDB

Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.

Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.

http://www.wikidata.org/entity/Q36078852

about

MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA Gut Microbiota Imbalance and Base Excision Repair Dynamics in Colon Cancer Structure and mechanism of DNA polymerase β Base excision repair A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.Irreversible inhibition of DNA polymerase β by small-molecule mimics of a DNA lesion Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β.Base excision repair: a critical player in many games A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated Variant Sequence context modulation of polycyclic aromatic hydrocarbon-induced mutagenesis.Human PrimPol mutation associated with high myopia has a DNA replication defect."Gate-keeper" residues and active-site rearrangements in DNA polymerase μ help discriminate non-cognate nucleotides.Involvement of DNA polymerase β overexpression in the malignant transformation induced by benzo[a]pyrene.Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells.Human POLB gene is mutated in high percentage of colorectal tumors.The K167I variant of DNA polymerase β that is found in Esophageal Carcinoma patients impairs polymerase activity and BER.Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks Transcriptional profiling reveals elevated Sox2 in DNA polymerase ß null mouse embryonic fibroblasts.R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity Cellular roles of DNA polymerase beta.Regulation of DNA Alkylation Damage Repair: Lessons and Therapeutic Opportunities.DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy.Base excision repair of oxidative DNA damage: from mechanism to disease.Genome instability caused by a germline mutation in the human DNA repair gene POLB.DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.Base Excision Repair Variants in Cancer.

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P2860

Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.

http://www.wikidata.org/entity/Q36078852

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Colon cancer-associated DNA po ...... y and cellular transformation.

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Colon cancer-associated DNA po ...... y and cellular transformation.

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type

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Colon cancer-associated DNA po ...... y and cellular transformation.

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Colon cancer-associated DNA po ...... y and cellular transformation.

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Colon cancer-associated DNA po ...... y and cellular transformation.

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Colon cancer-associated DNA po ...... y and cellular transformation.

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JBC.M112.362111

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Journal of Biological Chemistry

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Colon cancer-associated DNA po ...... y and cellular transformation.

@en

P2093

Antonia A Nemec

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Drew L Murphy

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Joachim Jaeger

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Joann B Sweasy

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Katherine A Donigan

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P2860

AP endonuclease-independent DNA base excision repair in human cells

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation.

Repair and genetic consequences of endogenous DNA base damage in mammalian cells.

Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage.

A review comparing deoxyribonucleoside triphosphate (dNTP) concentrations in the mitochondrial and cytoplasmic compartments of normal and transformed cells

Metal-induced DNA translocation leads to DNA polymerase conformational activation.

Human POLB gene is mutated in high percentage of colorectal tumors.

The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient.

Helper-independent transformation by unintegrated Harvey sarcoma virus DNA

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23840-23849

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scholarly article

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10.1074/JBC.M112.362111

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28

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2012-05-09T00:00:00Z

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3390657

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