Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.
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MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNAGut Microbiota Imbalance and Base Excision Repair Dynamics in Colon CancerStructure and mechanism of DNA polymerase βBase excision repairA germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformationThe S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.Irreversible inhibition of DNA polymerase β by small-molecule mimics of a DNA lesionRemote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β.Base excision repair: a critical player in many gamesA Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated VariantSequence context modulation of polycyclic aromatic hydrocarbon-induced mutagenesis.Human PrimPol mutation associated with high myopia has a DNA replication defect."Gate-keeper" residues and active-site rearrangements in DNA polymerase μ help discriminate non-cognate nucleotides.Involvement of DNA polymerase β overexpression in the malignant transformation induced by benzo[a]pyrene.Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells.Human POLB gene is mutated in high percentage of colorectal tumors.The K167I variant of DNA polymerase β that is found in Esophageal Carcinoma patients impairs polymerase activity and BER.Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaksTranscriptional profiling reveals elevated Sox2 in DNA polymerase ß null mouse embryonic fibroblasts.R152C DNA Pol β mutation impairs base excision repair and induces cellular transformationEpistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicityCellular roles of DNA polymerase beta.Regulation of DNA Alkylation Damage Repair: Lessons and Therapeutic Opportunities.DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy.Base excision repair of oxidative DNA damage: from mechanism to disease.Genome instability caused by a germline mutation in the human DNA repair gene POLB.DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.Base Excision Repair Variants in Cancer.
P2860
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P2860
Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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name
Colon cancer-associated DNA po ...... y and cellular transformation.
@ast
Colon cancer-associated DNA po ...... y and cellular transformation.
@en
type
label
Colon cancer-associated DNA po ...... y and cellular transformation.
@ast
Colon cancer-associated DNA po ...... y and cellular transformation.
@en
prefLabel
Colon cancer-associated DNA po ...... y and cellular transformation.
@ast
Colon cancer-associated DNA po ...... y and cellular transformation.
@en
P2093
P2860
P356
P1476
Colon cancer-associated DNA po ...... y and cellular transformation.
@en
P2093
Antonia A Nemec
Drew L Murphy
Joachim Jaeger
Joann B Sweasy
Katherine A Donigan
P2860
P304
23840-23849
P356
10.1074/JBC.M112.362111
P407
P577
2012-05-09T00:00:00Z