Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases
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Protein phosphatases and Alzheimer's diseaseQuantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon.The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in DrosophilaGlaucoma: the retina and beyondRotenone-dependent changes of anterograde motor protein expression and mitochondrial mobility in brain areas related to neurodegenerative diseasesHeat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neuronsALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation.Roles of tau protein in health and disease.Phosphoregulation of Tau modulates inhibition of kinesin-1 motility.Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer's Disease.Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potencyThe intersection of amyloid beta and tau at synapses in Alzheimer's diseaseGSK3β is involved in the relief of mitochondria pausing in a Tau-dependent mannerPrion-promoted phosphorylation of heterologous amyloid is coupled with ubiquitin-proteasome system inhibition and toxicity.Tau interconverts between diffusive and stable populations on the microtubule surface in an isoform and lattice specific manner.Reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant P301S tau.At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology.Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnosticsTau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.Secondary nucleating sequences affect kinetics and thermodynamics of tau aggregation.Regulation of human MAPT gene expression.Using Human iPSC-Derived Neurons to Model TAU Aggregation.The neuropathology of chronic traumatic encephalopathy.Gene Therapy Models of Alzheimer's Disease and Other Dementias.The Protective Effect of Icariin on Mitochondrial Transport and Distribution in Primary Hippocampal Neurons from 3× Tg-AD Mice.TOC1: characterization of a selective oligomeric tau antibody.The sphingolipid psychosine inhibits fast axonal transport in Krabbe disease by activation of GSK3β and deregulation of molecular motors.Tau pathology-mediated presynaptic dysfunctionCharacterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy.Tau as a therapeutic target in neurodegenerative disease.Cytosolic carboxypeptidase 5 removes α- and γ-linked glutamates from tubulin.Global axonal transport rates are unaltered in htau mice in vivo.Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline.Novel Non-phosphorylated Serine 9/21 GSK3β/α Antibodies: Expanding the Tools for Studying GSK3 RegulationAzaphilones inhibit tau aggregation and dissolve tau aggregates in vitroHIV Glycoprotein Gp120 Impairs Fast Axonal Transport by Activating Tak1 Signaling Pathways.Tau protein modifications and interactions: their role in function and dysfunction.Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study.Beyond amyloid: getting real about nonamyloid targets in Alzheimer's disease.
P2860
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P2860
Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Pathogenic forms of tau inhibi ...... of axonal phosphotransferases
@ast
Pathogenic forms of tau inhibi ...... of axonal phosphotransferases
@en
type
label
Pathogenic forms of tau inhibi ...... of axonal phosphotransferases
@ast
Pathogenic forms of tau inhibi ...... of axonal phosphotransferases
@en
prefLabel
Pathogenic forms of tau inhibi ...... of axonal phosphotransferases
@ast
Pathogenic forms of tau inhibi ...... of axonal phosphotransferases
@en
P2093
P2860
P1476
Pathogenic forms of tau inhibi ...... of axonal phosphotransferases
@en
P2093
Athena Andreadis
Gerardo A Morfini
Gustavo F Pigino
Kristina R Patterson
Lester I Binder
Nicholas M Kanaan
Nichole E LaPointe
Scott T Brady
P2860
P304
P356
10.1523/JNEUROSCI.0560-11.2011
P407
P577
2011-07-01T00:00:00Z