Preventing the degradation of mps1 at centrosomes is sufficient to cause centrosome reduplication in human cells. - Wikidata - wikimedia - TriplyDB

Preventing the degradation of mps1 at centrosomes is sufficient to cause centrosome reduplication in human cells.

Preventing the degradation of mps1 at centrosomes is sufficient to cause centrosome reduplication in human cells.

http://www.wikidata.org/entity/Q36095688

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Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer Centriole assembly and the role of Mps1: defensible or dispensable?Cep76, a centrosomal protein that specifically restrains centriole reduplication Ab ovo or de novo? Mechanisms of centriole duplication Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function Antizyme inhibitor 1: a potential carcinogenic molecule Centrosome - a promising anti-cancer target Structural and functional characterization of the protein kinase Mps1 in Arabidopsis thaliana The MPS1 family of protein kinases.Control of centrin stability by Aurora A.Centriole reduplication during prolonged interphase requires procentriole maturation governed by Plk1.Degradation of the human mitotic checkpoint kinase Mps1 is cell cycle-regulated by APC-cCdc20 and APC-cCdh1 ubiquitin ligases.VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes.Antizyme restrains centrosome amplification by regulating the accumulation of Mps1 at centrosomes VDAC3 and Mps1 negatively regulate ciliogenesis.Mps1 phosphorylation sites regulate the function of centrin 2 in centriole assembly.CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity.The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification.CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci Mip1 associates with both the Mps1 kinase and actin, and is required for cell cortex stability and anaphase spindle positioning.Spatial regulation of the spindle assembly checkpoint and anaphase-promoting complex in Aspergillus nidulans An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma.Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer.Quantitative immunofluorescence assay to measure the variation in protein levels at centrosomes.Involvement of Antizyme Characterized from the Small Abalone Haliotis diversicolor in Gonadal Development Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes centrin 2 function.Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function.Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint.Steroidogenic factor 1 (NR5A1) maintains centrosome homeostasis in steroidogenic cells by restricting centrosomal DNA-dependent protein kinase activation Delocalization of the microtubule motor Dynein from mitotic spindles by the human papillomavirus E7 oncoprotein is not sufficient for induction of multipolar mitoses Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation Modular elements of the TPR domain in the Mps1 N terminus differentially target Mps1 to the centrosome and kinetochore.The benefits of local depletion: The centrosome as a scaffold for ubiquitin-proteasome-mediated degradation Show me your license, please: deregulation of centriole duplication mechanisms that promote amplification.The centrosome: a prospective entrant in cancer therapy.Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma.Mps1 as a link between centrosomes and genomic instability.ECRG2 disruption leads to centrosome amplification and spindle checkpoint defects contributing chromosome instability.Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels.Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity

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P2860

Preventing the degradation of mps1 at centrosomes is sufficient to cause centrosome reduplication in human cells.

http://www.wikidata.org/entity/Q36095688

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2007 nî lūn-bûn

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Preventing the degradation of ...... reduplication in human cells.

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Preventing the degradation of ...... reduplication in human cells.

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MBC.E07-03-0283

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Molecular Biology of the Cell

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Preventing the degradation of ...... reduplication in human cells.

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Adlina Mohd Yusof

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Ching-Hui Yang

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Christopher Kasbek

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Harold A Fisk

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Heather M Chapman

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Mark Winey

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P2860

Proteomic characterization of the human centrosome by protein correlation profiling

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.

Centrosome amplification drives chromosomal instability in breast tumor development.

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability

The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

Cyclin-dependent kinase control of centrosome duplication

Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores

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4457-4469

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10.1091/MBC.E07-03-0283

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11

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18

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2043537

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