MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
about
Unwinding and rewinding: double faces of helicase?RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stabilityBLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasomeMaintaining Genome Stability in Defiance of Mitotic DNA DamageCrystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125Characterization of novel MPS1 inhibitors with preclinical anticancer activityChk2 prevents mitotic exit when the majority of kinetochores are unattached.Mitotic crisis: the unmasking of a novel role for RPAThe MPS1 family of protein kinases.Mps1 phosphorylation of condensin II controls chromosome condensation at the onset of mitosis.Regulation of BLM Nucleolar LocalizationChk1-dependent constitutive phosphorylation of BLM helicase at serine 646 decreases after DNA damage.The role of post-translational modifications in fine-tuning BLM helicase function during DNA repairActivation of Mps1 promotes transforming growth factor-beta-independent Smad signaling.Physical and functional interaction between mortalin and Mps1 kinase.TTK/hMPS1 is an attractive therapeutic target for triple-negative breast cancer.Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants.TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.Preventing the degradation of mps1 at centrosomes is sufficient to cause centrosome reduplication in human cells.Homologous recombination and its regulationA highly efficient multifunctional tandem affinity purification approach applicable to diverse organisms.Accumulation and Phosphorylation of RecQ-Mediated Genome Instability Protein 1 (RMI1) at Serine 284 and Serine 292 during Mitosis.Phosphorylation-dependent interactions of BLM and 53BP1 are required for their anti-recombinogenic roles during homologous recombination.Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition.Controlling DNA-end resection: a new task for CDKs.From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18.Monopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III α-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activatioRecQ helicases: multiple structures for multiple functions?RecQ helicases; at the crossroad of genome replication, repair, and recombination.Triple-negative breast cancer: investigating potential molecular therapeutic target.Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability.TP53 mutation-correlated genes predict the risk of tumor relapse and identify MPS1 as a potential therapeutic kinase in TP53-mutated breast cancers.Mitotic Kinases and p53 Signaling.On BLM helicase in recombination-mediated telomere maintenance.High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint.Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis
P2860
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P2860
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
@ast
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
@en
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
@nl
type
label
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
@ast
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
@en
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
@nl
prefLabel
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
@ast
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
@en
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
@nl
P2093
P2860
P3181
P356
P1476
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.0601828103
P407
P577
2006-08-01T00:00:00Z