Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation
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Spatiotemporal control of mitosis by the conserved spindle matrix protein MegatorSmall-molecule kinase inhibitors provide insight into Mps1 cell cycle functionA TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora BStructural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1UV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochoresMutational analysis of TTK gene in gastric and colorectal cancers with microsatellite instability.The MPS1 family of protein kinases.Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacyDissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversinePhosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.Dynamic autophosphorylation of mps1 kinase is required for faithful mitotic progressionCellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment.Differential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signalingMip1 associates with both the Mps1 kinase and actin, and is required for cell cortex stability and anaphase spindle positioning.A putative N-terminal nuclear export sequence is sufficient for Mps1 nuclear exclusion during interphaseTwo LXXLL motifs in the N terminus of Mps1 are required for Mps1 nuclear import during G(2)/M transition and sustained spindle checkpoint responses.A motif from Lys216 to Lys222 in human BUB3 protein is a nuclear localization signal and critical for BUB3 function in mitotic checkpoint.Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases.Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1.Selective killing of p53-deficient cancer cells by SP600125.Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expressionThe composition, functions, and regulation of the budding yeast kinetochoreMps1 kinase regulates tumor cell viability via its novel role in mitochondriaMonopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complexTTK is a favorable prognostic biomarker for triple-negative breast cancer survival.Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer.Mps1 is SUMO-modified during the cell cycle.Playing polo during mitosis: PLK1 takes the lead.Kinase signaling in the spindle checkpoint.Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint.CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.Identification of differentially expressed genes and signaling pathways in ovarian cancer by integrated bioinformatics analysis.Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis
P2860
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P2860
Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Regulation of kinetochore recr ...... oteins by Mps1 phosphorylation
@en
Regulation of kinetochore recr ...... teins by Mps1 phosphorylation.
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type
label
Regulation of kinetochore recr ...... oteins by Mps1 phosphorylation
@en
Regulation of kinetochore recr ...... teins by Mps1 phosphorylation.
@nl
prefLabel
Regulation of kinetochore recr ...... oteins by Mps1 phosphorylation
@en
Regulation of kinetochore recr ...... teins by Mps1 phosphorylation.
@nl
P2093
P2860
P356
P1476
Regulation of kinetochore recr ...... oteins by Mps1 phosphorylation
@en
P2093
Natalie Ahn
Quanbin Xu
Songcheng Zhu
Xiaojuan Zhang
P2860
P356
10.1091/MBC.E08-03-0324
P577
2008-10-15T00:00:00Z