Mechanisms of neurosteroid interactions with GABA(A) receptors. - Wikidata - wikimedia - TriplyDB

Mechanisms of neurosteroid interactions with GABA(A) receptors.

Mechanisms of neurosteroid interactions with GABA(A) receptors.

http://www.wikidata.org/entity/Q36102032

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The dark side of 5α-reductase inhibitors' therapy: sexual dysfunction, high Gleason grade prostate cancer and depression Interactions of L-3,5,3'-Triiodothyronine [corrected], Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding Modes A predicted binding site for cholesterol on the GABAA receptor GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway.Ethanol alters local cellular levels of (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP) independent of the adrenals in subcortical brain regions.Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation.Neurosteroid, GABAergic and hypothalamic pituitary adrenal (HPA) axis regulation: what is the current state of knowledge in humans?Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies.Palmitoylethanolamide stimulation induces allopregnanolone synthesis in C6 Cells and primary astrocytes: involvement of peroxisome-proliferator activated receptor-α.Ethanol administration produces divergent changes in GABAergic neuroactive steroid immunohistochemistry in the rat brain.Specificity of cholesterol and analogs to modulate BK channels points to direct sterol-channel protein interactions Rapid Throughput Analysis of GABAA Receptor Subtype Modulators and Blockers Using DiSBAC1(3) Membrane Potential Red Dye.11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice A portable site: a binding element for 17β-estradiol can be placed on any subunit of a nicotinic α4β2 receptor The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors The effect of age on the discriminative stimulus effects of ethanol and its GABA(A) receptor mediation in cynomolgus monkeys.Synthetic neurosteroids on brain protection Use of concatemers of ligand-gated ion channel subunits to study mechanisms of steroid potentiation.Effects of positive and negative modulators of the γ-aminobutyric acid A receptor complex on responding under a differential-reinforcement-of-low-rate schedule of reinforcement in rats.Large conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol.Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors.Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research.Neurosteroids, stress and depression: potential therapeutic opportunities.Effects on membrane capacitance of steroids with antagonist properties at GABAA receptors Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic δGABA(A) Receptors.A novel, rapid, inhibitory effect of insulin on alpha1beta2gamma2s gamma-aminobutyric acid type A receptors.Etifoxine improves sensorimotor deficits and reduces glial activation, neuronal degeneration, and neuroinflammation in a rat model of traumatic brain injury.The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction.ent-Steroids: novel tools for studies of signaling pathways.Anxiolytic-like effect of hydroalcoholic extract of ripe pistachio hulls in adult female Wistar rats and its possible mechanisms.The influence of the membrane on neurosteroid actions at GABA(A) receptors.Acute and chronic effects of ethanol on learning-related synaptic plasticity.Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α,5α-THP and reduces long-term operant ethanol self-administration.Progesterone in the clinical treatment of acute traumatic brain injury.Microtubule ionic conduction and its implications for higher cognitive functions.The discovery of new anesthetics by targeting GABA(A) receptors.A mutant residue in the third transmembrane region of the GABA(A) alpha1 subunit causes increased agonistic neurosteroid responses.

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Mechanisms of neurosteroid interactions with GABA(A) receptors.

http://www.wikidata.org/entity/Q36102032

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2007 nî lūn-bûn

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Mechanisms of neurosteroid interactions with GABA(A) receptors.

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Mechanisms of neurosteroid interactions with GABA(A) receptors.

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Mechanisms of neurosteroid interactions with GABA(A) receptors.

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Mechanisms of neurosteroid interactions with GABA(A) receptors.

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Mechanisms of neurosteroid interactions with GABA(A) receptors.

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Mechanisms of neurosteroid interactions with GABA(A) receptors.

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J.PHARMTHERA.2007.03.004

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Pharmacology & Therapeutics

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Mechanisms of neurosteroid interactions with GABA(A) receptors

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Alex S Evers

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Charles F Zorumski

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Douglas F Covey

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Gustav Akk

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Joe Henry Steinbach

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P2860

Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513

Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors

Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes

Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

Differential modulation of the gamma-aminobutyric acid type C receptor by neuroactive steroids

Neurosteroids: biochemistry and clinical significance

The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors

Neurosteroids: endogenous regulators of the GABA(A) receptor

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10.1016/J.PHARMTHERA.2007.03.004

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