ent-Steroids: novel tools for studies of signaling pathways.
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Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural formsSide-chain oxysterols modulate cholesterol accessibility through membrane remodeling.Enantioselective protein-sterol interactions mediate regulation of both prokaryotic and eukaryotic inward rectifier K+ channels by cholesterol.Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.Tunable recognition of the steroid alpha-face by adjacent pi-electron density.Cholesterol tuning of BK ethanol response is enantioselective, and is a function of accompanying lipids.Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ₂₅₋₃₅ peptide-induced toxicity in vitro and in vivo in micePsychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture.Pregnenolone sulfate and its enantiomer: differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient miceIdentification of a cholesterol-binding pocket in inward rectifier K(+) (Kir) channels.Synthetic neurosteroids on brain protectionNeurosteroids, stress and depression: potential therapeutic opportunities.Identification of novel cholesterol-binding regions in Kir2 channels.Concise Synthesis of the Unnatural Sphingosine and Psychosine Enantiomer.Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.The influence of the membrane on neurosteroid actions at GABA(A) receptors.Progesterone in the clinical treatment of acute traumatic brain injury.Anticancer steroids: linking natural and semi-synthetic compounds.Structural Stringency of Cholesterol for Membrane Protein Function Utilizing Stereoisomers as Novel Tools: A Review.The sticky issue of neurosteroids and GABA(A) receptors.Oxysterols are allosteric activators of the oncoprotein Smoothened.Membrane dipole potential is sensitive to cholesterol stereospecificity: implications for receptor function.Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network.Stereospecific requirement of cholesterol in the function of the serotonin1A receptorStructural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels.A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibitionSynthetic nat- or ent-steroids in as few as five chemical steps from epichlorohydrin.Cyanobacterial ent-Sterol-Like Natural Products from a Deviated Ubiquinone Pathway.Steroids and Brain, a Rising Bio-Medical Domain: a Perspective.
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ent-Steroids: novel tools for studies of signaling pathways.
description
article científic
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article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 03 December 2008
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
ent-Steroids: novel tools for studies of signaling pathways.
@en
ent-Steroids: novel tools for studies of signaling pathways.
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type
label
ent-Steroids: novel tools for studies of signaling pathways.
@en
ent-Steroids: novel tools for studies of signaling pathways.
@nl
prefLabel
ent-Steroids: novel tools for studies of signaling pathways.
@en
ent-Steroids: novel tools for studies of signaling pathways.
@nl
P2860
P1433
P1476
ent-Steroids: novel tools for studies of signaling pathways.
@en
P2093
Douglas F Covey
P2860
P304
P356
10.1016/J.STEROIDS.2008.11.019
P577
2008-12-03T00:00:00Z