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A critical role for the transcription factor Scl in platelet production during stress thrombopoiesisAn investigation on platelet transport during thrombus formation at micro-scale stenosisMouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodentsSequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophilsPI 3-kinase p110beta: a new target for antithrombotic therapyPlatelets and the injured vessel wall-- "rolling into action": focus on glycoprotein Ib/V/IX and the platelet cytoskeletonErythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular injuryPhosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interactionDok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in miceNew insights into the haemostatic function of platelets.Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target.Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets.Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function.Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets.A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance.Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway.Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.Class I phosphoinositide 3-kinases.Antiplatelet therapy: in search of the 'magic bullet'.Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in miceImaging signaling processes in platelets.Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoformType I phosphoinositide 3-kinases: potential antithrombotic targets?A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complexThe impact of blood rheology on the molecular and cellular events underlying arterial thrombosis.Specific function of phosphoinositide 3-kinase beta in the control of DNA replication.14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.Dynamics of platelet thrombus formation.Procoagulant platelets: are they necrotic?The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading.Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration.Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors.Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.Improved analogs and novel delivery systems for somatostatin octapeptides.The bioactive phospholipid, lysophosphatidylcholine, induces cellular effects via G-protein-dependent activation of adenylyl cyclase.Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha.Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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name
Shaun P Jackson
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Shaun P Jackson
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Shaun P Jackson
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Shaun P Jackson
@nl
Shaun P Jackson
@sl
type
label
Shaun P Jackson
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Shaun P Jackson
@en
Shaun P Jackson
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Shaun P Jackson
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Shaun P Jackson
@sl
prefLabel
Shaun P Jackson
@ast
Shaun P Jackson
@en
Shaun P Jackson
@es
Shaun P Jackson
@nl
Shaun P Jackson
@sl
P108
P106
P108
P31
P496
0000-0002-4750-1991