A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop
about
Posttranscriptional regulation of p53 and its targets by RNA-binding proteinsShizukaol D isolated from Chloranthus japonicas inhibits AMPK-dependent lipid content in hepatic cells by inducing mitochondrial dysfunctionRapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapyIntegrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis.A protein turnover signaling motif controls the stimulus-sensitivity of stress response pathwaysDeficiency of insulin-like growth factor-1 receptor confers resistance to oxidative stress in C2C12 myoblastsThe Blocking of c-Met Signaling Induces Apoptosis through the Increase of p53 Protein in Lung Cancer.The MDM2-p53 pathway revisitedCrosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor.Molecular and cellular biology of rhabdomyosarcoma.The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis.The E3 ubiquitin protein ligase MDM2 dictates all-trans retinoic acid-induced osteoblastic differentiation of osteosarcoma cells by modulating the degradation of RARα.MDM2 expression is repressed by the RNA-binding protein RNPC1 via mRNA stability.Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA.Targeting the p53 Pathway in Ewing Sarcoma.The IGF-1R/AKT pathway determines cell fate in response to p53.Protein tyrosine kinase pathway-derived ROS/NO productions contribute to G2/M cell cycle arrest in evodiamine-treated human cervix carcinoma HeLa cells.Carbonate apatite nanoparticles carry siRNA(s) targeting growth factor receptor genes egfr1 and erbb2 to regress mouse breast tumor.MDM2 is overexpressed and regulated by the eukaryotic translation initiation factor 4E (eIF4E) in human squamous cell carcinoma of esophagus.bFGF enhances the IGFs-mediated pluripotent and differentiation potentials in multipotent stem cells.p53 and metabolism: from mechanism to therapeutics.
P2860
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P2860
A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
A novel role for IGF-1R in p53 ...... of the p53-Mdm2 feedback loop
@ast
A novel role for IGF-1R in p53 ...... of the p53-Mdm2 feedback loop
@en
type
label
A novel role for IGF-1R in p53 ...... of the p53-Mdm2 feedback loop
@ast
A novel role for IGF-1R in p53 ...... of the p53-Mdm2 feedback loop
@en
prefLabel
A novel role for IGF-1R in p53 ...... of the p53-Mdm2 feedback loop
@ast
A novel role for IGF-1R in p53 ...... of the p53-Mdm2 feedback loop
@en
P2093
P2860
P356
P1476
A novel role for IGF-1R in p53 ...... of the p53-Mdm2 feedback loop
@en
P2093
P2860
P304
P356
10.1083/JCB.200703044
P407
P577
2007-09-01T00:00:00Z