Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans-Golgi network
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Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer's DiseaseRole of the Retromer Complex in Neurodegenerative DiseasesGolgi fragmentation in Alzheimer's diseaseThe Possible Roles of the Dentate Granule Cell's Leptin and Other Ciliary Receptors in Alzheimer's NeuropathologyDual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptideMitochondrial dysfunction: different routes to Alzheimer's disease therapyHSV-1 and Alzheimer's disease: more than a hypothesis.Cargo trafficking in Alzheimer’s disease: the possible role of retromerSORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.Dual-tagged amyloid-β precursor protein reveals distinct transport pathways of its N- and C-terminal fragmentsA paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.The use of pharmacological retromer chaperones in Alzheimer's disease and other endosomal-related disorders.Chronic treatment with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576 mouse model of Alzheimer's disease.Advances with RNA interference in Alzheimer's disease research.Retromer: a master conductor of endosome sorting.The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.A membrane proximal helix in the cytosolic domain of the human APP interacting protein LR11/SorLA deforms liposomes.Cyclopamine modulates γ-secretase-mediated cleavage of amyloid precursor protein by altering its subcellular trafficking and lysosomal degradationGenome-Wide Analyses of Working-Memory Ability: A Review.The Na+/H+ exchanger NHE6 modulates endosomal pH to control processing of amyloid precursor protein in a cell culture model of Alzheimer disease.Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β proteinLINGO-1 promotes lysosomal degradation of amyloid-β protein precursor.The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons.Specific antibody binding to the APP672-699 region shifts APP processing from α- to β-cleavageThe Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain.Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes.Endothelin-converting enzymes degrade intracellular β-amyloid produced within the endosomal/lysosomal pathway and autophagosomes.Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway.δ-COP modulates Aβ peptide formation via retrograde trafficking of APPRelevance of the COPI complex for Alzheimer's disease progression in vivoRecruitment of the Mint3 adaptor is necessary for export of the amyloid precursor protein (APP) from the Golgi complexRNA silencing of genes involved in Alzheimer's disease enhances mitochondrial function and synaptic activity.Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system.Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain.F-box only protein 2 (Fbxo2) regulates amyloid precursor protein levels and processing.Aβ-induced Golgi fragmentation in Alzheimer's disease enhances Aβ production.Role of endosomes and lysosomes in human disease.Environmental exposure to lead (Pb) and variations in its susceptibility.Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling.
P2860
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P2860
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans-Golgi network
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Amyloid precursor protein (APP ...... ion in the trans-Golgi network
@ast
Amyloid precursor protein (APP ...... ion in the trans-Golgi network
@en
type
label
Amyloid precursor protein (APP ...... ion in the trans-Golgi network
@ast
Amyloid precursor protein (APP ...... ion in the trans-Golgi network
@en
prefLabel
Amyloid precursor protein (APP ...... ion in the trans-Golgi network
@ast
Amyloid precursor protein (APP ...... ion in the trans-Golgi network
@en
P2860
P356
P1476
Amyloid precursor protein (APP ...... ion in the trans-Golgi network
@en
P2093
Regina Wai-Yan Choy
Zhiliang Cheng
P2860
P304
P356
10.1073/PNAS.1208635109
P407
P577
2012-06-18T00:00:00Z