Recombinant approaches to IgG-like bispecific antibodies.
about
Advances in Antibody DesignCODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.Designed auto-assembly of nanostreptabodies for rapid tissue-specific targeting in vivo.A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptorInhibiting complement regulators in cancer immunotherapy with bispecific mAbs.Single variable domain-IgG fusion. A novel recombinant approach to Fc domain-containing bispecific antibodies.Application of the Fc fusion format to generate tag-free bi-specific diabodies.A modular IgG-scFv bispecific antibody topology.Engineering of stable bispecific antibodies targeting IL-17A and IL-23.Stability engineering of scFvs for the development of bispecific and multivalent antibodies.Engineering an antibody with picomolar affinity to DOTA chelates of multiple radionuclides for pretargeted radioimmunotherapy and imaging.A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo.IgG-single chain Fv fusion protein therapeutic for Alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey.Her2-specific multivalent adapters confer designed tropism to adenovirus for gene targetingDevelopment of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling.Rapid optimization and prototyping for therapeutic antibody-like molecules.Strategies to stabilize compact folding and minimize aggregation of antibody-based fragmentsImmunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodiesCancer Imaging and Therapy with Bispecific Antibody Pretargeting.Improving target cell specificity using a novel monovalent bispecific IgG designRearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokineticsA bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cellsFusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation.Simultaneous blockade of VEGF and Dll4 by HD105, a bispecific antibody, inhibits tumor progression and angiogenesis.Application of bispecific antibody against antigen and hapten for immunodetection and immunopurification.Use of uteroglobin for the engineering of polyvalent, polyspecific fusion proteins.Bispecific antibodies for cancer therapy.Research and development of next generation of antibody-based therapeuticsCurrent strategies in antibody engineering: Fc engineering and pH-dependent antigen binding, bispecific antibodies and antibody drug conjugates.Potential applications of designed ankyrin repeat proteins in diagnostics and therapeutics.Re-engineering therapeutic antibodies for Alzheimer's disease as blood-brain barrier penetrating bi-specific antibodies.Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis.Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR.Engineering and characterization of a bispecific HER2 x EGFR-binding affibody molecule.Highly effective recombinant format of a humanized IgG-like bispecific antibody for cancer immunotherapy with retargeting of lymphocytes to tumor cells.Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence.Insights into the molecular basis of a bispecific antibody's target selectivity.Molecular construction and optimization of anti-human IL-1alpha/beta dual variable domain immunoglobulin (DVD-Ig) molecules.The Gyrolab™ immunoassay system: a platform for automated bioanalysis and rapid sample turnaround.
P2860
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P2860
Recombinant approaches to IgG-like bispecific antibodies.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Recombinant approaches to IgG-like bispecific antibodies.
@ast
Recombinant approaches to IgG-like bispecific antibodies.
@en
type
label
Recombinant approaches to IgG-like bispecific antibodies.
@ast
Recombinant approaches to IgG-like bispecific antibodies.
@en
prefLabel
Recombinant approaches to IgG-like bispecific antibodies.
@ast
Recombinant approaches to IgG-like bispecific antibodies.
@en
P2860
P1476
Recombinant approaches to IgG-like bispecific antibodies.
@en
P2093
Jonathan S Marvin
Zhenping Zhu
P2860
P304
P356
10.1111/J.1745-7254.2005.00119.X
P577
2005-06-01T00:00:00Z
P5875
P6179
1040765598