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Preadministration of High-Dose Salicylates, Suppressors of NF- B Activation, May Increase the Chemosensitivity of Many Cancers: An Example of Proapoptotic Signal Modulation TherapyProteasome inhibitors induce apoptosis in human lung cancer cells through a positive feedback mechanism and the subsequent Mcl-1 protein cleavageMitochondrial Stat3, the Need for Design ThinkingThe role of obesity in gastrointestinal cancer: evidence and opinionSTAT3 inhibitors for cancer therapy: Have all roads been explored?Tagging of genomic STAT3 and STAT1 with fluorescent proteins and insertion of a luciferase reporter in the cyclin D1 gene provides a modified A549 cell line to screen for selective STAT3 inhibitorsIL-6-mediated activation of Stat3α prevents trauma/hemorrhagic shock-induced liver inflammationSTAT3 as a therapeutic target in head and neck cancerModeling gene expression regulatory networks with the sparse vector autoregressive modelChemical probes that competitively and selectively inhibit Stat3 activationGaliellalactone inhibits stem cell-like ALDH-positive prostate cancer cellsAnticancer compound plumbagin and its molecular targets: a structural insight into the inhibitory mechanisms using computational approachesIn vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin BJSI-124 suppresses invasion and angiogenesis of glioblastoma cells in vitroHCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell linesMolecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and Nrf-2 signalling.High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines.Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway.Enhancing or eliminating signals for cell survival to treat disease.STAT3 Inhibition as a Therapeutic Strategy for Chordoma.Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end.Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells.Cucurbitacin I induces protective autophagy in glioblastoma in vitro and in vivoTherapeutic modulators of STAT signalling for human diseasesTargeting protein-protein interactions for therapeutic intervention: a challenge for the future.A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-κB.Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B leukemic cells.YLT192, a novel, orally active bioavailable inhibitor of VEGFR2 signaling with potent antiangiogenic activity and antitumor efficacy in preclinical modelsBiomarker robustness reveals the PDGF network as driving disease outcome in ovarian cancer patients in multiple studies.Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer.Alternative ways of modulating JAK-STAT pathway: Looking beyond phosphorylation.STAT3 signaling: anticancer strategies and challenges.(-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer.Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity.ING4 enhances paclitaxel's effect on colorectal cancer growth in vitro and in vivoB7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation.Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesisDietary compounds as potent inhibitors of the signal transducers and activators of transcription (STAT) 3 regulatory network.Inhibition of janus kinase 2 by compound AG490 suppresses the proliferation of MDA-MB-231 cells via up-regulating SARI (suppressor of AP-1, regulated by IFN).Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Targeting Stat3 in cancer therapy.
@ast
Targeting Stat3 in cancer therapy.
@en
type
label
Targeting Stat3 in cancer therapy.
@ast
Targeting Stat3 in cancer therapy.
@en
prefLabel
Targeting Stat3 in cancer therapy.
@ast
Targeting Stat3 in cancer therapy.
@en
P1433
P1476
Targeting Stat3 in cancer therapy.
@en
P2093
David J Tweardy
Naijie Jing
P304
P356
10.1097/00001813-200507000-00002
P577
2005-07-01T00:00:00Z