Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells.
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Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificitiesIGF-IR: a new prognostic biomarker for human glioblastomaBlocking transcription of the human rhodopsin gene by triplex-mediated DNA photocrosslinkingRole of receptor tyrosine kinases and their ligands in glioblastoma.Treatment of murine breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor decreases the level of plasminogen activator transcripts, inhibits cell growth in vitro, and reduces tumorigenesis in vivo.Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis.The contradictions of the insulin-like growth factor 1 receptor.Triplex-forming molecules: from concepts to applications.Triplex targeting of human PDGF-B (c-sis, proto-oncogene) promoter specifically inhibits factors binding and PDGF-B transcriptionAntagonists of growth hormone-releasing hormone inhibit the growth of U-87MG human glioblastoma in nude mice.Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor.Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility.The role of IGF-1R in pediatric malignancies.Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.Inhibition of Erythroleukemia Cell Growth by Triplex-forming RNAsMonitoring DNA triplex formation using multicolor fluorescence and application to insulin-like growth factor I promoter downregulation.Selective inhibition of the human tie-1 promoter with triplex-forming oligonucleotides targeted to Ets binding sitesAntiproliferative activity of a triplex-forming oligonucleotide recognizing a Ki-ras polypurine/polypyrimidine motif correlates with protein binding.Design and structural analysis of hairpin-TFO for transcriptional activation of genes in S. cerevisiae.Triplex forming oligonucleotide targeted to 3'UTR downregulates the expression of the bcl-2 proto-oncogene in HeLa cells.DNA meets synthetic polymers--highly versatile hybrid materials.Impaired Shc, Ras, and MAPK activation but normal Akt activation in FL5.12 cells expressing an insulin-like growth factor I receptor mutated at tyrosines 1250 and 1251.Transient activation of Jun N-terminal kinases and protection from apoptosis by the insulin-like growth factor I receptor can be suppressed by dicumarol.Synthetic peptide sequence from the C-terminus of the insulin-like growth factor-I receptor that induces apoptosis and inhibition of tumor growth.Dissociation between resistance to apoptosis and the transformed phenotype in IGF-I receptor signaling.Anti-apoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion.Human glioma cells transformed by IGF-I triple helix technology show immune and apoptotic characteristics determining cell selection for gene therapy of glioblastoma.Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit.RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death.Recombinant adenoviruses expressing dominant negative insulin-like growth factor-I receptor demonstrate antitumor effects on lung cancer.Regulation of dual-specificity phosphatases M3/6 and hVH5 by phorbol esters. Analysis of a delta-like domain.Hedgehog/GLI1 regulates IGF dependent malignant behaviors in glioma stem cells.PDGFR and IGF-1R Inhibitors Induce a G2/M Arrest and Subsequent Cell Death in Human Glioblastoma Cell Lines
P2860
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P2860
Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Suppression of insulin-like gr ...... of rat C6 glioblastoma cells.
@ast
Suppression of insulin-like gr ...... of rat C6 glioblastoma cells.
@en
type
label
Suppression of insulin-like gr ...... of rat C6 glioblastoma cells.
@ast
Suppression of insulin-like gr ...... of rat C6 glioblastoma cells.
@en
prefLabel
Suppression of insulin-like gr ...... of rat C6 glioblastoma cells.
@ast
Suppression of insulin-like gr ...... of rat C6 glioblastoma cells.
@en
P2093
P2860
P356
P1476
Suppression of insulin-like gr ...... of rat C6 glioblastoma cells.
@en
P2093
C L Chernicky
F Rininsland
P Burfeind
T R Johnson
P2860
P304
P356
10.1073/PNAS.94.11.5854
P407
P577
1997-05-01T00:00:00Z