A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions.
about
Darwinian evolution of prions in cell cultureCofactor molecules maintain infectious conformation and restrict strain properties in purified prionsUnraveling prion strains with cell biology and organic chemistryCellular aspects of prion replication in vitroIntraperitoneal Infection of Wild-Type Mice with Synthetically Generated Mammalian PrionEx vivo mammalian prions are formed of paired double helical prion protein fibrils.Crystal structure of human prion protein bound to a therapeutic antibodyAnti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc)Acquisition of drug resistance and dependence by prionsTetracysteine-tagged prion protein allows discrimination between the native and converted formsIsolation of proteinase K-sensitive prions using pronase E and phosphotungstic acidPhysical, chemical and kinetic factors affecting prion infectivityPrion amyloid structure explains templating: how proteins can be genes.Identification of a gene regulatory network associated with prion replication.Effect of hydrophobic mutations in the H2-H3 subdomain of prion protein on stability and conversion in vitro and in vivo.Molecular Mechanisms of Chronic Wasting Disease Prion Propagation.The expanding universe of prion diseases.Direct detection of soil-bound prions.The comprehensive native interactome of a fully functional tagged prion proteinParacrine diffusion of PrP(C) and propagation of prion infectivity by plasma membrane-derived microvesiclesPathologic prion protein infects cells by lipid-raft dependent macropinocytosisPrion strain discrimination based on rapid in vivo amplification and analysis by the cell panel assayUnexpected tolerance of alpha-cleavage of the prion protein to sequence variationsLiposome-siRNA-peptide complexes cross the blood-brain barrier and significantly decrease PrP on neuronal cells and PrP in infected cell cultures.Infection of cell lines with experimental and natural ovine scrapie agents.Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassaysPrion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked.Conservation of a glycine-rich region in the prion protein is required for uptake of prion infectivityQuantitative detection and biological propagation of scrapie seeding activity in vitro facilitate use of prions as model pathogens for disinfectionA simple, versatile and sensitive cell-based assay for prions from various speciesCell-based quantification of chronic wasting disease prions.White blood cell-based detection of asymptomatic scrapie infection by ex vivo assaysSpontaneous generation of mammalian prionsIs there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles?Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner.Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection.N-terminal domain of prion protein directs its oligomeric association.Male-killing Wolbachia do not protect Drosophila bifasciata against viral infection.Quantitative recovery of scrapie agent with minimal protein from highly infectious cultures.Pharmacological chaperone for the structured domain of human prion protein.
P2860
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P2860
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions.
@ast
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions.
@en
type
label
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions.
@ast
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions.
@en
prefLabel
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions.
@ast
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions.
@en
P2093
P2860
P356
P1476
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions.
@en
P2093
P2860
P304
11666-11671
P356
10.1073/PNAS.1834432100
P407
P577
2003-09-22T00:00:00Z