A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.
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Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion diseaseSmall RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cellsCellular aspects of prion replication in vitroInvestigating the spreading and toxicity of prion-like proteins using the metazoan model organism C. elegansPrion protein accumulation in lipid rafts of mouse aging brainNSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expressionLive imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and websSystematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets.Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.Lipid rafts and clathrin cooperate in the internalization of PrP in epithelial FRT cellsGlimepiride reduces the expression of PrPc, prevents PrPSc formation and protects against prion mediated neurotoxicity in cell lines.Cellular biology of prion diseases.Epidemiological mechanisms of genetic resistance to kuru.Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion proteinAmphotericin B inhibits the generation of the scrapie isoform of the prion protein in infected cultures.Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody.Scrapie strains maintain biological phenotypes on propagation in a cell line in culture.Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.Rapid disease development in scrapie-infected mice deficient for CD40 ligandActivation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting diseaseA genome-wide survey for prion-regulated miRNAs associated with cholesterol homeostasisMouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res.PrP polymorphisms tightly control sheep prion replication in cultured cellsThe Functional Role of Prion Protein (PrPC) on Autophagy.Cultured peripheral neuroglial cells are highly permissive to sheep prion infection.A bovine cell line that can be infected by natural sheep scrapie prions.Prion infection of mouse neurospheres.Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion proteinThe neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes.Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion proteinPrions on the move.Prion infection impairs the cellular response to oxidative stressMicroglial cell line established from prion protein-overexpressing mice is susceptible to various murine prion strainsPrions impair bioaminergic functions through serotonin- or catecholamine-derived neurotoxins in neuronal cells.Phosphorothioate oligonucleotides reduce PrP levels and prion infectivity in cultured cells.Prion infection of muscle cells in vitroTransgenic over-expression of mammalian heparanase delays prion disease onset and progression.Can Urine Metabolomics Be Helpful in Differentiating Neuropathic and Nociceptive Pain? A Proof-of-Concept Study.Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death.
P2860
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P2860
A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
A hypothalamic neuronal cell l ...... pie prions exhibits apoptosis.
@ast
A hypothalamic neuronal cell l ...... pie prions exhibits apoptosis.
@en
type
label
A hypothalamic neuronal cell l ...... pie prions exhibits apoptosis.
@ast
A hypothalamic neuronal cell l ...... pie prions exhibits apoptosis.
@en
prefLabel
A hypothalamic neuronal cell l ...... pie prions exhibits apoptosis.
@ast
A hypothalamic neuronal cell l ...... pie prions exhibits apoptosis.
@en
P2093
P2860
P1433
P1476
A hypothalamic neuronal cell l ...... apie prions exhibits apoptosis
@en
P2093
D M Holtzman
H M Schätzl
R I Weiner
S J DeArmond
W C Mobley
P2860
P304
P407
P577
1997-11-01T00:00:00Z