The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus. - Wikidata - wikimedia - TriplyDB

The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus.

The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus.

http://www.wikidata.org/entity/Q36161960

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Splicing Regulation: A Molecular Device to Enhance Cancer Cell Adaptation Posttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biology RNA-binding proteins in neurodegeneration: Seq and you shall receive Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer Phosphorylation-mediated regulation of alternative splicing in cancer The role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progression Context-dependent control of alternative splicing by RNA-binding proteins Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer SRPK1 and Akt Protein Kinases Phosphorylate the RS Domain of Lamin B Receptor with Distinct Specificity: A Combined Biochemical and In Silico Approach Paraquat modulates alternative pre-mRNA splicing by modifying the intracellular distribution of SRPK2 JMJD6 and U2AF65 co-regulate alternative splicing in both JMJD6 enzymatic activity dependent and independent manner.Modulation the alternative splicing of GLA (IVS4+919G>A) in Fabry disease.Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells.Akt-ing up on SRPK1: oncogene or tumor suppressor?The role of mRNA splicing in prostate cancer.Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma The splicing activator DAZAP1 integrates splicing control into MEK/Erk-regulated cell proliferation and migration.Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate.Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase.Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.The RNAissance family: SR proteins as multifaceted regulators of gene expression Epidermal growth-factor-induced transcript isoform variation drives mammary cell migration.ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.Advances in therapeutic development for spinal muscular atrophy.Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing Induced transcription and stability of CELF2 mRNA drives widespread alternative splicing during T-cell signaling Alternative RNA splicing and cancer Mechanisms for U2AF to define 3' splice sites and regulate alternative splicing in the human genome Intra-domain Cross-talk Regulates Serine-arginine Protein Kinase 1-dependent Phosphorylation and Splicing Function of Transformer 2β1 SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing.Alternative Splicing of Toll-Like Receptor 9 Transcript in Teleost Fish Grouper Is Regulated by NF-κB Signaling via Phosphorylation of the C-Terminal Domain of the RPB1 Subunit of RNA Polymerase II Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation.Evidence for disulfide bonds in SR Protein Kinase 1 (SRPK1) that are required for activity and nuclear localization Dysregulation of splicing proteins in head and neck squamous cell carcinoma.Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.Heterogeneous nuclear ribonucleoproteins A1 and A2 modulate expression of Tid1 isoforms and EGFR signaling in non-small cell lung cancer.The intracellular fate of zonula occludens 2 is regulated by the phosphorylation of SR repeats and the phosphorylation/O-GlcNAcylation of S257.

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P2860

The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus.

http://www.wikidata.org/entity/Q36161960

description

2012 nî lūn-bûn

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name

The Akt-SRPK-SR axis constitut ...... ative splicing in the nucleus.

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The Akt-SRPK-SR axis constitut ...... ative splicing in the nucleus.

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type

label

The Akt-SRPK-SR axis constitut ...... ative splicing in the nucleus.

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The Akt-SRPK-SR axis constitut ...... ative splicing in the nucleus.

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prefLabel

The Akt-SRPK-SR axis constitut ...... ative splicing in the nucleus.

@ast

The Akt-SRPK-SR axis constitut ...... ative splicing in the nucleus.

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The Akt-SRPK-SR axis constitut ...... ative splicing in the nucleus.

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Gourisanker Ghosh

http://www.w3.org/2001/XMLSchema#string

Hairi Li

http://www.w3.org/2001/XMLSchema#string

Jinsong Qiu

http://www.w3.org/2001/XMLSchema#string

Joseph A Adams

http://www.w3.org/2001/XMLSchema#string

Michael G Rosenfeld

http://www.w3.org/2001/XMLSchema#string

Qidong Hu

http://www.w3.org/2001/XMLSchema#string

Ryan M Plocinik

http://www.w3.org/2001/XMLSchema#string

Wen Liu

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Xiang-Dong Fu

http://www.w3.org/2001/XMLSchema#string

Yu Zhou

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P2860

Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing

Dynamic protein-protein interaction wiring of the human spliceosome

SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells

Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.

Processive phosphorylation of alternative splicing factor/splicing factor 2

The structure of Sky1p reveals a novel mechanism for constitutive activity

Conservation in budding yeast of a kinase specific for SR splicing factors.

Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty

Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acid

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3

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47

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2012-06-21T00:00:00Z

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228061735

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22727668

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3418396

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