Gsα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsα mutations
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Overlapping mouse subcongenic strains successfully separate two linked body fat QTL on distal MMU 2.Gsα deficiency in the dorsomedial hypothalamus underlies obesity associated with Gsα mutations.Gsα Deficiency in the Ventromedial Hypothalamus Enhances Leptin Sensitivity and Improves Glucose Homeostasis in Mice on a High-Fat Diet.An essential role for the K+-dependent Na+/Ca2+-exchanger, NCKX4, in melanocortin-4-receptor-dependent satiety.The role of genomic imprinting in biology and disease: an expanding view.Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasisG(q/11)α and G(s)α mediate distinct physiological responses to central melanocortinsReductions in hypothalamic Gfap expression, glial cells and α-tanycytes in lean and hypermetabolic Gnasxl-deficient miceNew Perspectives on Genomic Imprinting, an Essential and Multifaceted Mode of Epigenetic Control in the Developing and Adult Brain.Melanocortin-4 receptor-regulated energy homeostasisPro-Opiomelanocortin (POMC) Neurones, POMC-Derived Peptides, Melanocortin Receptors and Obesity: How Understanding of this System has Changed Over the Last Decade.The Role of the Melanocortin System in Metabolic Disease: New Developments and Advances.Biased signaling at neural melanocortin receptors in regulation of energy homeostasis.Elevated blood pressure, heart rate and body temperature in mice lacking the XLαs protein of the Gnas locus is due to increased sympathetic tone.Lipid stress inhibits endocytosis of melanocortin-4 receptor from modified clathrin-enriched sites and impairs receptor desensitization.Melanocortin 4 receptor activation inhibits presynaptic N-type calcium channels in amygdaloid complex neurons.Genetic and epigenetic defects at the GNAS locus lead to distinct patterns of skeletal growth but similar early-onset obesity.
P2860
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P2860
Gsα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsα mutations
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2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
@zh-hk
2012年論文
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2012年論文
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2012年论文
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2012年论文
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2012年论文
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name
Gsα deficiency in the paravent ...... associated with Gsα mutations
@ast
Gsα deficiency in the paravent ...... associated with Gsα mutations
@en
type
label
Gsα deficiency in the paravent ...... associated with Gsα mutations
@ast
Gsα deficiency in the paravent ...... associated with Gsα mutations
@en
prefLabel
Gsα deficiency in the paravent ...... associated with Gsα mutations
@ast
Gsα deficiency in the paravent ...... associated with Gsα mutations
@en
P2093
P2860
P356
P1433
P1476
Gsα deficiency in the paravent ...... associated with Gsα mutations
@en
P2093
Ahmed Kablan
Alta Berger
Jiandi Zhang
Lee S Weinstein
Oksana Gavrilova
P2860
P304
P356
10.1210/EN.2012-1113
P407
P577
2012-06-25T00:00:00Z