Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. - Wikidata - wikimedia - TriplyDB

Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.

Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.

http://www.wikidata.org/entity/Q33821507

about

Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway The GNAS complex locus and human diseases associated with loss-of-function mutations or epimutations within this imprinted gene Synthesis and secretion of renin in mice with induced genetic mutations Gene Dosage Effects at the Imprinted Gnas Cluster A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity Removal of the N-terminal extension of cardiac troponin I as a functional compensation for impaired myocardial beta-adrenergic signaling Increased prevalence of carpal tunnel syndrome in albright hereditary osteodystrophy Transgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivo Maternal inheritance of the Gnas cluster mutation Ex1A-T affects size, implicating NESP55 in growth The emergence of human-evolutionary medical genomics Overlapping mouse subcongenic strains successfully separate two linked body fat QTL on distal MMU 2.Gsα deficiency in the dorsomedial hypothalamus underlies obesity associated with Gsα mutations.Gsα Deficiency in the Ventromedial Hypothalamus Enhances Leptin Sensitivity and Improves Glucose Homeostasis in Mice on a High-Fat Diet.Development of vascular renin expression in the kidney critically depends on the cyclic AMP pathway Patterns of hybrid loss of imprinting reveal tissue- and cluster-specific regulation Familial History of Diabetes is Associated with Poor Glycaemic Control in Type 2 Diabetics: A Cross-sectional Study.DNA sequence polymorphisms within the bovine guanine nucleotide-binding protein Gs subunit alpha (Gsα)-encoding (GNAS) genomic imprinting domain are associated with performance traits G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis Heterotopic ossifications in a mouse model of albright hereditary osteodystrophy Association of maternally inherited GNAS alleles with African-American male birth weight The role of GNAS and other imprinted genes in the development of obesity.Postnatal changes in the expression pattern of the imprinted signalling protein XLαs underlie the changing phenotype of deficient mice.Eating behaviors in obese children with pseudohypoparathyroidism type 1a: a cross-sectional study.The role of genomic imprinting in biology and disease: an expanding view.A mouse model for osseous heteroplasia The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice Dietary alleviation of maternal obesity and diabetes: increased resistance to diet-induced obesity transcriptional and epigenetic signatures.Effects of deficiency of the G protein Gsα on energy and glucose homeostasis Progressive osseous heteroplasia: diagnosis, treatment, and prognosis Improved fatigue resistance in Gsα-deficient and aging mouse skeletal muscles due to adaptive increases in slow fibers.Loss of methylation at GNAS exon A/B is associated with increased intrauterine growth Extra-long Gαs variant XLαs protein escapes activation-induced subcellular redistribution and is able to provide sustained signaling GNAS Spectrum of Disorders.New mutations at the imprinted Gnas cluster show gene dosage effects of Gsα in postnatal growth and implicate XLαs in bone and fat metabolism but not in suckling.G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis.Loss of XLαs (extra-large αs) imprinting results in early postnatal hypoglycemia and lethality in a mouse model of pseudohypoparathyroidism Ib.Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.Paternally inherited gsα mutation impairs adipogenesis and potentiates a lean phenotype in vivo.Gsα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsα mutations The G protein α subunit variant XLαs promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo.

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P2860

Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.

http://www.wikidata.org/entity/Q33821507

description

2005 nî lūn-bûn

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2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2005 թվականի մայիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.

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Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.

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type

label

Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.

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Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.

@en

prefLabel

Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.

@ast

Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.

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PNAS.0408268102

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Proceedings of the National Academy of Sciences of the United States of America

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Alternative Gnas gene products have opposite effects on glucose and lipid metabolism

@en

P2093

Annie T Nguyen

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Chuxia Deng

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Javier Lorenzo

http://www.w3.org/2001/XMLSchema#string

Jie Liu

http://www.w3.org/2001/XMLSchema#string

Laura Shen

http://www.w3.org/2001/XMLSchema#string

Lisa M Nackers

http://www.w3.org/2001/XMLSchema#string

Min Chen

http://www.w3.org/2001/XMLSchema#string

Oksana Gavrilova

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Tao Xie

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P2860

Neuroendocrine secretory protein 55 (NESP55): alternative splicing onto transcripts of the GNAS gene and posttranslational processing of a maternally expressed protein

Fibroblast growth factor receptor 3 is a negative regulator of bone growth

Imprinting of the G(s)alpha gene GNAS1 in the pathogenesis of acromegaly

Troglitazone action is independent of adipose tissue

Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit

Paternal versus maternal transmission of a stimulatory G-protein alpha subunit knockout produces opposite effects on energy metabolism

Bidirectional imprinting of a single gene: GNAS1 encodes maternally, paternally, and biallelically derived proteins

A comprehensive transcript map of the mouse Gnas imprinted complex.

Imprinted Nesp55 influences behavioral reactivity to novel environments

Identification of a methylation imprint mark within the mouse Gnas locus.

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10.1073/PNAS.0408268102

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20

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102

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Lee S. Weinstein

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2005-05-09T00:00:00Z

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7858487

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15883378

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1129092

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