DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation.
about
Nijmegen breakage syndrome (NBS)The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutationEndonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regionsMobile elements reveal small population size in the ancient ancestors of Homo sapiensA role for DRAK2 in the germinal center reaction and the antibody responseRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationHoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutationMicroRNAs in B-cells: from normal differentiation to treatment of malignanciesEstrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutationMutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand breakScaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.Mismatch-mediated error prone repair at the immunoglobulin genes.Transcription-associated mutagenesis in yeast is directly proportional to the level of gene expression and influenced by the direction of DNA replication.A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.B-cell receptor activation inhibits AID expression through calmodulin inhibition of E-proteins.DNA repair in antibody somatic hypermutation.DNA replication to aid somatic hypermutationAID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4Mouse models of DNA polymerases.Immunomodulation and lymphoma in humans.The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 functionHeavy chain-only antibodies are spontaneously produced in light chain-deficient mice.Biased dA/dT somatic hypermutation as regulated by the heavy chain intronic iEmu enhancer and 3'Ealpha enhancers in human lymphoblastoid B cells.Long non-coding RNAs in B-cell malignancies: a comprehensive overview.AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.Immunodeficiency in Bloom's Syndrome.Expression of activation-induced cytidine deaminase splicing variants in patients with ankylosing spondylitis.
P2860
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P2860
DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
DNA lesions and repair in immu ...... ion and somatic hypermutation.
@ast
DNA lesions and repair in immu ...... ion and somatic hypermutation.
@en
type
label
DNA lesions and repair in immu ...... ion and somatic hypermutation.
@ast
DNA lesions and repair in immu ...... ion and somatic hypermutation.
@en
prefLabel
DNA lesions and repair in immu ...... ion and somatic hypermutation.
@ast
DNA lesions and repair in immu ...... ion and somatic hypermutation.
@en
P2093
P2860
P356
P1476
DNA lesions and repair in immu ...... ion and somatic hypermutation.
@en
P2093
Albert J Evinger
Paolo Casali
Yuan Zhong
Zhenming Xu
Zsolt Fulop
P2860
P304
P356
10.1196/ANNALS.1313.119
P407
P577
2005-06-01T00:00:00Z