AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.
about
Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regionsRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationHoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutationAltered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC proteinElucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutationLupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.Iron inhibits activation-induced cytidine deaminase enzymatic activity and modulates immunoglobulin class switch DNA recombination.DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AIDImmunoglobulin class-switch DNA recombination: induction, targeting and beyond.AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination.Engineering and optimising deaminase fusions for genome editing.Attenuating homologous recombination stimulates an AID-induced antileukemic effect.14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination.Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination
P2860
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P2860
AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
AID- and Ung-dependent generat ...... a post-cleavage role for AID.
@en
type
label
AID- and Ung-dependent generat ...... a post-cleavage role for AID.
@en
prefLabel
AID- and Ung-dependent generat ...... a post-cleavage role for AID.
@en
P2860
P1433
P1476
AID- and Ung-dependent generat ...... a post-cleavage role for AID.
@en
P2093
Paolo Casali
P2860
P356
10.1016/J.MOLIMM.2008.07.003
P577
2008-08-28T00:00:00Z