Endogenous antigen tunes the responsiveness of naive B cells but not T cells
about
Anergic B Cells: Precarious On-Call Warriors at the Nexus of Autoimmunity and False-Flagged PathogensThe Timing of T Cell Priming and CyclingThe outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergyThe role of T cell receptor signaling thresholds in guiding T cell fate decisionsB lymphocyte antigen receptor signaling: initiation, amplification, and regulationHepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in MiceImmune history profoundly affects broadly protective B cell responses to influenza.Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns.Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development.Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.Bruton's tyrosine kinase promotes persistence of mature anti-insulin B cells.Altered B cell signalling in autoimmunity.B cell receptor signaling-based index as a biomarker for the loss of peripheral immune tolerance in autoreactive B cells in rheumatoid arthritis.Pivotal Functions of Plasmacytoid Dendritic Cells in Systemic Autoimmune Pathogenesis.A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.CD4+ T cells and CD40 participate in selection and homeostasis of peripheral B cells.Responsiveness of B cells is regulated by the hinge region of IgD.A mouse variable gene fragment binds to DNA independently of the BCR context: a possible role for immature B-cell repertoire establishment.Characterization of antigen-specific B cells using nominal antigen-coated flow-beads.TGFβ activated kinase 1 (TAK1) at the crossroad of B cell receptor and Toll-like receptor 9 signaling pathways in human B cells.Establishment of murine gammaherpesvirus latency in B cells is not a stochastic event.General Approach for Tetramer-Based Identification of Autoantigen-Reactive B Cells: Characterization of La- and snRNP-Reactive B Cells in Autoimmune BXD2 MiceDNA vaccine molecular adjuvants SP-D-BAFF and SP-D-APRIL enhance anti-gp120 immune response and increase HIV-1 neutralizing antibody titersA Novel Transgenic Mouse Line for Tracing MicroRNA-155-5p Activity In Vivo.mTOR-Dependent and Independent Survival Signaling by PI3K in B Lymphocytes.Autopolyreactivity Confers a Holistic Role in the Immune System.Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral ToleranceAltered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome.Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2.BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells.Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation.CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursorsIndependent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte MemoryA mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance.Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells.Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.Pro-inflammatory self-reactive T cells are found within murine TCR-αβ(+) CD4(-) CD8(-) PD-1(+) cells.
P2860
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P2860
Endogenous antigen tunes the responsiveness of naive B cells but not T cells
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Endogenous antigen tunes the responsiveness of naive B cells but not T cells
@ast
Endogenous antigen tunes the responsiveness of naive B cells but not T cells
@en
type
label
Endogenous antigen tunes the responsiveness of naive B cells but not T cells
@ast
Endogenous antigen tunes the responsiveness of naive B cells but not T cells
@en
prefLabel
Endogenous antigen tunes the responsiveness of naive B cells but not T cells
@ast
Endogenous antigen tunes the responsiveness of naive B cells but not T cells
@en
P2860
P356
P1433
P1476
Endogenous antigen tunes the responsiveness of naive B cells but not T cells
@en
P2093
Ramya Parameswaran
P2860
P2888
P304
P356
10.1038/NATURE11311
P407
P577
2012-09-01T00:00:00Z
P5875
P6179
1004633454