Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62.
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Selective interaction of JNK protein kinase isoforms with transcription factorsInteraction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivationMKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathwayThe N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitroGlycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulationA comprehensive pathway map of epidermal growth factor receptor signalingRegulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinaseRole of 14-3-3epsilon, c-Myc/Max, and Akt phosphorylation in HIV-1 gp 120-induced mesangial cell proliferationNegative control of the Myc protein by the stress-responsive kinase Pak2Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitroDestabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathwayThe Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cellsActivation of mitogen-activated protein kinase cascade regulates pituitary tumor-transforming gene transactivation function.Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms.Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoterNew Myc-interacting proteins: a second Myc network emerges.MYC oncogenes and human neoplastic disease.Mad1 function is regulated through elements within the carboxy terminusHuman c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster.The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidenceReal-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infectionListeria monocytogenes, an invasive bacterium, stimulates MAP kinase upon attachment to epithelial cells.Regulation of the Warburg effect in early-passage breast cancer cells.A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum.Apparent uncoupling of oncogenicity from fibroblast transformation and apoptosis in a mutant myc gene transduced by feline leukemia virus.Detection of activity centers in cellular pathways using transcript profiling.Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesisSerum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus.Expression of the c-myc proto-oncogene is essential for HIV-1 infection in activated T cells.A comprehensive map of the toll-like receptor signaling network.A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain.Immortalization and transformation of human mammary epithelial cells by a tumor-derived Myc mutant.Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis.Transactivation of the human p53 tumor suppressor gene by c-Myc/Max contributes to elevated mutant p53 expression in some tumors.Cell cycle regulation of the c-Myc transcriptional activation domain.AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma.Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity.Posttranslational regulation of Myc by promyelocytic leukemia zinc finger protein.Sin3 corepressor function in Myc-induced transcription and transformation.Multifunctional roles of enolase in Alzheimer's disease brain: beyond altered glucose metabolism.
P2860
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P2860
Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Transactivation of gene expres ...... ation sites Thr-58 and Ser-62.
@ast
Transactivation of gene expres ...... ation sites Thr-58 and Ser-62.
@en
type
label
Transactivation of gene expres ...... ation sites Thr-58 and Ser-62.
@ast
Transactivation of gene expres ...... ation sites Thr-58 and Ser-62.
@en
prefLabel
Transactivation of gene expres ...... ation sites Thr-58 and Ser-62.
@ast
Transactivation of gene expres ...... ation sites Thr-58 and Ser-62.
@en
P2093
P2860
P356
P1476
Transactivation of gene expres ...... ation sites Thr-58 and Ser-62.
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.8.3216
P407
P577
1993-04-01T00:00:00Z