Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation
about
Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cellsThe multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cellsTCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeysLiver is able to activate naïve CD8+ T cells with dysfunctional anti-viral activity in the murine system.Localized populations of CD8 MHC class I tetramer SIV-specific T cells in lymphoid follicles and genital epitheliumTracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hostsIL-12 is required for mTOR regulation of memory CTLs during viral infection.Transcriptional profiling of peripheral CD8+T cell responses to SIVΔnef and SIVmac251 challenge reveals a link between protective immunity and induction of systemic immunoregulatory mechanisms.Cd8 enhancer E8I and Runx factors regulate CD8α expression in activated CD8+ T cellsProgrammed cell death 1 and Helios distinguish TCR-αβ+ double-negative (CD4-CD8-) T cells that derive from self-reactive CD8 T cellsRepetitive peptide boosting progressively enhances functional memory CTLsCD8low CD100- T Cells Identify a Novel CD8 T Cell Subset Associated with Viral Control during Human Hantaan Virus Infection.Transient CD8-memory contraction: a potential contributor to latent cytomegalovirus reactivation.Modulation of MHC binding by lateral association of TCR and coreceptor.TLR agonists are highly effective at eliciting functional memory CTLs of effector memory phenotype in peptide immunization.Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors.Enhancing the Tumor Selectivity of a Picornavirus Virotherapy Promotes Tumor Regression and the Accumulation of Infiltrating CD8+ T Cells.Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 inductionCD8 down-regulation and functional impairment of SIV-specific cytotoxic T lymphocytes in lymphoid and mucosal tissues during SIV infection.Nicotine inhibits memory CTL programmingPro-inflammatory self-reactive T cells are found within murine TCR-αβ(+) CD4(-) CD8(-) PD-1(+) cells.Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and V alpha 2 down-regulation.Self-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levelsCognate antigen stimulation generates potent CD8(+) inflammatory effector T cells.An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriageEpigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas.Functional avidity: a measure to predict the efficacy of effector T cells?Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy.Amino acids and immune response: a role for cysteine, glutamine, phenylalanine, tryptophan and arginine in T-cell function and cancer?Enhanced cytotoxicity and decreased CD8 dependence of human cancer-specific cytotoxic T lymphocytes after vaccination with low peptide dose.High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells.Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo.Combined PI3K/Akt and Hsp90 targeting synergistically suppresses essential functions of alloreactive T cells and increases Tregs.Hepatic compartmentalization of exhausted and regulatory cells in HIV/HCV-coinfected patients.Complete but curtailed T-cell response to very low-affinity antigenGuidelines for the use of flow cytometry and cell sorting in immunological studies.Suppression of antigen-specific T cell responses by the Kaposi's sarcoma-associated herpesvirus viral OX2 protein and its cellular orthologue, CD200.Selective induction of CTL helper rather than killer activity by natural epitope variants promotes dendritic cell-mediated HIV-1 dissemination.Epitope specificity and relative clonal abundance do not affect CD8 differentiation patterns during lymphocytic choriomeningitis virus infection
P2860
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P2860
Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Detuning CD8 T cells: down-reg ...... response during CTL activation
@ast
Detuning CD8 T cells: down-reg ...... response during CTL activation
@en
type
label
Detuning CD8 T cells: down-reg ...... response during CTL activation
@ast
Detuning CD8 T cells: down-reg ...... response during CTL activation
@en
prefLabel
Detuning CD8 T cells: down-reg ...... response during CTL activation
@ast
Detuning CD8 T cells: down-reg ...... response during CTL activation
@en
P2093
P2860
P356
P1476
Detuning CD8 T cells: down-reg ...... response during CTL activation
@en
P2093
Matthew F Mescher
Stephen C Jameson
Zhengguo Xiao
P2860
P304
P356
10.1084/JEM.20062376
P407
P577
2007-10-22T00:00:00Z