The amino terminus of GLUT4 functions as an internalization motif but not an intracellular retention signal when substituted for the transferrin receptor cytoplasmic domain
about
Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes.Golgi localization and functionally important domains in the NH2 and COOH terminus of the yeast CLC putative chloride channel Gef1p.CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-CblMultiple endocytic signals in the C-terminal tail of the cystic fibrosis transmembrane conductance regulatorPerturbation of dynamin II with an amphiphysin SH3 domain increases GLUT4 glucose transporters at the plasma membrane in 3T3-L1 adipocytes. Dynamin II participates in GLUT4 endocytosis.Identification of amino acid residues within the C terminus of the Glut4 glucose transporter that are essential for insulin-stimulated redistribution to the plasma membrane.High basal cell surface levels of fish GLUT4 are related to reduced sensitivity of insulin-induced translocation toward GGA and AS160 inhibition in adipocytes.Reciprocal regulation of endocytosis and metabolismThe C-terminus of GLUT4 targets the transporter to the perinuclear compartment but not to the insulin-responsive vesiclesGLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif.A di-leucine sequence and a cluster of acidic amino acids are required for dynamic retention in the endosomal recycling compartment of fibroblasts.Insulin resistance, diabetes, and the insulin-regulated trafficking of GLUT-4.Insulin-sensitive targeting of the GLUT4 glucose transporter in L6 myoblasts is conferred by its COOH-terminal cytoplasmic tail.Molecular regulation of GLUT-4 targeting in 3T3-L1 adipocytes.Distinct signals in the GLUT4 glucose transporter for internalization and for targeting to an insulin-responsive compartment.Transferrin receptor containing the SDYQRL motif of TGN38 causes a reorganization of the recycling compartment but is not targeted to the TGNGLUT4 and transferrin receptor are differentially sorted along the endocytic pathway in CHO cellsIntracellular targeting of antigens internalized by membrane immunoglobulin in B lymphocytes.Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment.Functional roles of short sequence motifs in the endocytosis of membrane receptors.Topology mapping of insulin-regulated glucose transporter GLUT4 using computational biology.SARA, a FYVE domain protein, affects Rab5-mediated endocytosis.Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency.Molecular mechanisms controlling GLUT4 intracellular retention.GLUT4 is internalized by a cholesterol-dependent nystatin-sensitive mechanism inhibited by insulin.The cytosolic C-terminus of the glucose transporter GLUT4 contains an acidic cluster endosomal targeting motif distal to the dileucine signal.Subcellular trafficking kinetics of GLU4 mutated at the N- and C-terminal.Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells.A dual role of the N-terminal FQQI motif in GLUT4 trafficking.Characterization of the insulin-regulated endocytic recycling mechanism in 3T3-L1 adipocytes using a novel reporter molecule.Aldolase mediates the association of F-actin with the insulin-responsive glucose transporter GLUT4.Entry of newly synthesized GLUT4 into the insulin-responsive storage compartment is dependent upon both the amino terminus and the large cytoplasmic loop.Molecular identification of a glucose transporter from fish muscle.Identification of an insulin-responsive, slow endocytic recycling mechanism in Chinese hamster ovary cells.Di-leucine-mediated internalization of ligand by a truncated growth hormone receptor is independent of the ubiquitin conjugation system.Dynamics of insulin-stimulated translocation of GLUT4 in single living cells visualised using green fluorescent protein
P2860
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P2860
The amino terminus of GLUT4 functions as an internalization motif but not an intracellular retention signal when substituted for the transferrin receptor cytoplasmic domain
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
The amino terminus of GLUT4 fu ...... in receptor cytoplasmic domain
@ast
The amino terminus of GLUT4 fu ...... in receptor cytoplasmic domain
@en
type
label
The amino terminus of GLUT4 fu ...... in receptor cytoplasmic domain
@ast
The amino terminus of GLUT4 fu ...... in receptor cytoplasmic domain
@en
prefLabel
The amino terminus of GLUT4 fu ...... in receptor cytoplasmic domain
@ast
The amino terminus of GLUT4 fu ...... in receptor cytoplasmic domain
@en
P2093
P2860
P356
P1476
The amino terminus of GLUT4 fu ...... in receptor cytoplasmic domain
@en
P2093
R J Garippa
T E McGraw
P2860
P304
P356
10.1083/JCB.124.5.705
P407
P577
1994-03-01T00:00:00Z