Conformation gating as a mechanism for enzyme specificity.
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The association of tetrameric acetylcholinesterase with ColQ tail: a block normal mode analysis.Modeling protein association mechanisms and kineticsIntrinsic Localized Modes in ProteinsA structural snapshot of an intermediate on the streptavidin-biotin dissociation pathwayIschemic A/D transition of mitochondrial complex I and its role in ROS generationA wrench in the works of human acetylcholinesterase: soman induced conformational changes revealed by molecular dynamics simulationsGorge Motions of Acetylcholinesterase Revealed by Microsecond Molecular Dynamics Simulations.Catalytic transitions in the human MDR1 P-glycoprotein drug binding sites.Fisher's geometric model of adaptation meets the functional synthesis: data on pairwise epistasis for fitness yields insights into the shape and size of phenotype spaceConservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics.Gated Diffusion-controlled ReactionsLatrunculin analogues with improved biological profiles by "diverted total synthesis": preparation, evaluation, and computational analysis.Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds.Conformational heterogeneity of the M2 proton channel and a structural model for channel activationEnhancement of transport selectivity through nano-channels by non-specific competition.From induced fit to conformational selection: a continuum of binding mechanism controlled by the timescale of conformational transitionsA theory for the proton transport of the influenza virus M2 protein: extensive test against conductance dataStructure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction.Rational design of an enzyme mutant for anti-cocaine therapeuticsFundamental aspects of protein-protein association kineticsSubpicosecond conformational dynamics of small peptides probed by two-dimensional vibrational spectroscopy.Diffusion-Influenced Transport of Ions across a Transmembrane Channel with an Internal Binding Site.Analysis of a 10-ns molecular dynamics simulation of mouse acetylcholinesterase.Regulation of protein mobility via thermal membrane undulations.The dynamics of ligand barrier crossing inside the acetylcholinesterase gorgeDynamics of pinned membranes with application to protein diffusion on the surface of red blood cellsFinite element solution of the steady-state Smoluchowski equation for rate constant calculationsTetrameric mouse acetylcholinesterase: continuum diffusion rate calculations by solving the steady-state Smoluchowski equation using finite element methods.Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesteraseDistinct mechanisms of a phosphotyrosyl peptide binding to two SH2 domainsFinite Element Estimation of Protein-Ligand Association Rates with Post-Encounter Effects: Applications to Calcium binding in Troponin C and SERCA.Gated binding of ligands to HIV-1 protease: Brownian dynamics simulations in a coarse-grained model.Enhancing human spermine synthase activity by engineered mutationsTheory and simulation on the kinetics of protein-ligand binding coupled to conformational change.Finite element analysis of drug electrostatic diffusion: inhibition rate studies in N1 neuraminidase.Developing an energy landscape for the novel function of a (beta/alpha)8 barrel: ammonia conduction through HisF.Theory and simulation of diffusion-influenced, stochastically gated ligand binding to buried sites.Automated prediction of protein association rate constants.Numerical calculation of protein-ligand binding rates through solution of the Smoluchowski equation using smoothed particle hydrodynamicsFinite element analysis of the time-dependent Smoluchowski equation for acetylcholinesterase reaction rate calculations.
P2860
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P2860
Conformation gating as a mechanism for enzyme specificity.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Conformation gating as a mechanism for enzyme specificity.
@ast
Conformation gating as a mechanism for enzyme specificity.
@en
type
label
Conformation gating as a mechanism for enzyme specificity.
@ast
Conformation gating as a mechanism for enzyme specificity.
@en
prefLabel
Conformation gating as a mechanism for enzyme specificity.
@ast
Conformation gating as a mechanism for enzyme specificity.
@en
P2093
P2860
P356
P1476
Conformation gating as a mechanism for enzyme specificity.
@en
P2093
P2860
P304
P356
10.1073/PNAS.95.16.9280
P407
P577
1998-08-01T00:00:00Z